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Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes

This manuscript introduces a programable active bone fixator system that enables systematic investigation of bone healing processes in a sheep animal model. In contrast to previous systems, this solution combines the ability to precisely control the mechanical conditions acting within a fracture wit...

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Autores principales: Barcik, Jan, Ernst, Manuela, Dlaska, Constantin E., Drenchev, Ludmil, Zeiter, Stephan, Epari, Devakara R., Windolf, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792812/
https://www.ncbi.nlm.nih.gov/pubmed/33375087
http://dx.doi.org/10.3390/s21010017
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author Barcik, Jan
Ernst, Manuela
Dlaska, Constantin E.
Drenchev, Ludmil
Zeiter, Stephan
Epari, Devakara R.
Windolf, Markus
author_facet Barcik, Jan
Ernst, Manuela
Dlaska, Constantin E.
Drenchev, Ludmil
Zeiter, Stephan
Epari, Devakara R.
Windolf, Markus
author_sort Barcik, Jan
collection PubMed
description This manuscript introduces a programable active bone fixator system that enables systematic investigation of bone healing processes in a sheep animal model. In contrast to previous systems, this solution combines the ability to precisely control the mechanical conditions acting within a fracture with continuous monitoring of the healing progression and autonomous operation of the system throughout the experiment. The active fixator system was implemented on a double osteotomy model that shields the experimental fracture from the influence of the animal’s functional loading. A force sensor was integrated into the fixator to continuously measure stiffness of the repair tissue as an indicator for healing progression. A dedicated control unit was developed that allows programing of different loading protocols which are later executed autonomously by the active fixator. To verify the feasibility of the system, it was implanted in two sheep with different loading protocols, mimicking immediate and delayed weight-bearing, respectively. The implanted devices operated according to the programmed protocols and delivered seamless data over the whole course of the experiment. The in vivo trial confirmed the feasibility of the system. Hence, it can be applied in further preclinical studies to better understand the influence of mechanical conditions on fracture healing.
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spelling pubmed-77928122021-01-09 Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes Barcik, Jan Ernst, Manuela Dlaska, Constantin E. Drenchev, Ludmil Zeiter, Stephan Epari, Devakara R. Windolf, Markus Sensors (Basel) Article This manuscript introduces a programable active bone fixator system that enables systematic investigation of bone healing processes in a sheep animal model. In contrast to previous systems, this solution combines the ability to precisely control the mechanical conditions acting within a fracture with continuous monitoring of the healing progression and autonomous operation of the system throughout the experiment. The active fixator system was implemented on a double osteotomy model that shields the experimental fracture from the influence of the animal’s functional loading. A force sensor was integrated into the fixator to continuously measure stiffness of the repair tissue as an indicator for healing progression. A dedicated control unit was developed that allows programing of different loading protocols which are later executed autonomously by the active fixator. To verify the feasibility of the system, it was implanted in two sheep with different loading protocols, mimicking immediate and delayed weight-bearing, respectively. The implanted devices operated according to the programmed protocols and delivered seamless data over the whole course of the experiment. The in vivo trial confirmed the feasibility of the system. Hence, it can be applied in further preclinical studies to better understand the influence of mechanical conditions on fracture healing. MDPI 2020-12-22 /pmc/articles/PMC7792812/ /pubmed/33375087 http://dx.doi.org/10.3390/s21010017 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barcik, Jan
Ernst, Manuela
Dlaska, Constantin E.
Drenchev, Ludmil
Zeiter, Stephan
Epari, Devakara R.
Windolf, Markus
Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes
title Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes
title_full Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes
title_fullStr Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes
title_full_unstemmed Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes
title_short Programable Active Fixator System for Systematic In Vivo Investigation of Bone Healing Processes
title_sort programable active fixator system for systematic in vivo investigation of bone healing processes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792812/
https://www.ncbi.nlm.nih.gov/pubmed/33375087
http://dx.doi.org/10.3390/s21010017
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