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Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis

BACKGROUND: Liver cirrhosis is associated with cardiac dysfunction in 40%–60% of the patients. Serum NT-ProBNP is a potential additional marker of cirrhotic cardiomyopathy. MATERIALS AND METHODS: It was a cross-sectional analytical study done in a tertiary care center in South India on 100 patients...

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Autores principales: Singh, Ajmera Jail, Wyawahare, Mukta, Sarin, Krishna, Rajendiran, Soundravally, Subrahmanyam, Dharanipragada K. S., Satheesh, Santhosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792875/
https://www.ncbi.nlm.nih.gov/pubmed/33457338
http://dx.doi.org/10.4103/abr.abr_250_19
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author Singh, Ajmera Jail
Wyawahare, Mukta
Sarin, Krishna
Rajendiran, Soundravally
Subrahmanyam, Dharanipragada K. S.
Satheesh, Santhosh
author_facet Singh, Ajmera Jail
Wyawahare, Mukta
Sarin, Krishna
Rajendiran, Soundravally
Subrahmanyam, Dharanipragada K. S.
Satheesh, Santhosh
author_sort Singh, Ajmera Jail
collection PubMed
description BACKGROUND: Liver cirrhosis is associated with cardiac dysfunction in 40%–60% of the patients. Serum NT-ProBNP is a potential additional marker of cirrhotic cardiomyopathy. MATERIALS AND METHODS: It was a cross-sectional analytical study done in a tertiary care center in South India on 100 patients of cirrhosis of liver. Diastolic function was assessed from mitral inflow parameters as well as tissue Doppler imaging of the left ventricle in 95 patients. Serum NT-ProBNP levels was measured once at the time of inclusion into the study. Cirrhotic cardiomyopathy was diagnosed in those with abnormal echocardiographic parameters and its association with NT-Pro BNP levels was analyzed. Data were analyzed using SPSS version 22. RESULTS: Diastolic dysfunction was found in 40 (42.1%) participants. Twenty-two (23.2%) had Grade I, 16 (16.8%) had Grade II, and 2 (2.1%) had Grade III diastolic dysfunction. The mean NT-Pro-BNP was elevated (107.38 [±66.76] ng/ml) in patients with diastolic dysfunction. NT-ProBNP was higher in Child–Pugh B and C disease when compared to milder disease. NT-ProBNP was not a good screening tool for cardiomyopathy in cirrhotic patients. Area under the curve was 0.517 with 95% confidence interval and the P = 0.77. However, positive correlation was present between the NT-ProBNP value and two echocardiographic parameters of diastolic dysfunction (E/A, E/E'). CONCLUSION: Increased serum NT-ProBNP levels in cirrhosis of liver have a positive correlation with echocardiographic measures of diastolic dysfunction of the heart but it is not a good tool for screening for cirrhotic cardiomyopathy.
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spelling pubmed-77928752021-01-15 Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis Singh, Ajmera Jail Wyawahare, Mukta Sarin, Krishna Rajendiran, Soundravally Subrahmanyam, Dharanipragada K. S. Satheesh, Santhosh Adv Biomed Res Original Article BACKGROUND: Liver cirrhosis is associated with cardiac dysfunction in 40%–60% of the patients. Serum NT-ProBNP is a potential additional marker of cirrhotic cardiomyopathy. MATERIALS AND METHODS: It was a cross-sectional analytical study done in a tertiary care center in South India on 100 patients of cirrhosis of liver. Diastolic function was assessed from mitral inflow parameters as well as tissue Doppler imaging of the left ventricle in 95 patients. Serum NT-ProBNP levels was measured once at the time of inclusion into the study. Cirrhotic cardiomyopathy was diagnosed in those with abnormal echocardiographic parameters and its association with NT-Pro BNP levels was analyzed. Data were analyzed using SPSS version 22. RESULTS: Diastolic dysfunction was found in 40 (42.1%) participants. Twenty-two (23.2%) had Grade I, 16 (16.8%) had Grade II, and 2 (2.1%) had Grade III diastolic dysfunction. The mean NT-Pro-BNP was elevated (107.38 [±66.76] ng/ml) in patients with diastolic dysfunction. NT-ProBNP was higher in Child–Pugh B and C disease when compared to milder disease. NT-ProBNP was not a good screening tool for cardiomyopathy in cirrhotic patients. Area under the curve was 0.517 with 95% confidence interval and the P = 0.77. However, positive correlation was present between the NT-ProBNP value and two echocardiographic parameters of diastolic dysfunction (E/A, E/E'). CONCLUSION: Increased serum NT-ProBNP levels in cirrhosis of liver have a positive correlation with echocardiographic measures of diastolic dysfunction of the heart but it is not a good tool for screening for cirrhotic cardiomyopathy. Wolters Kluwer - Medknow 2020-10-30 /pmc/articles/PMC7792875/ /pubmed/33457338 http://dx.doi.org/10.4103/abr.abr_250_19 Text en Copyright: © 2020 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Singh, Ajmera Jail
Wyawahare, Mukta
Sarin, Krishna
Rajendiran, Soundravally
Subrahmanyam, Dharanipragada K. S.
Satheesh, Santhosh
Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis
title Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis
title_full Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis
title_fullStr Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis
title_full_unstemmed Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis
title_short Association of N- terminal Pro Brain Natriuretic Peptide with Echocardiographic Measures of Diastolic Dysfunction in Cirrhosis
title_sort association of n- terminal pro brain natriuretic peptide with echocardiographic measures of diastolic dysfunction in cirrhosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792875/
https://www.ncbi.nlm.nih.gov/pubmed/33457338
http://dx.doi.org/10.4103/abr.abr_250_19
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