Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning

A case is presented on a 40-year-old male with chronic lead poisoning with loss of consciousness, rhabdomyolysis, and acute renal failure after occupational exposure. Physical examination revealed generalized atrophy, tenderness, and swelling in the right limb and a decreased proximal muscle strengt...

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Autores principales: Ansari, Behnaz, Dorooshi, Gholamali, Lalehzar, Sahar Sadat, Taheri, Abolfazl, Meamar, Rokhsareh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792877/
https://www.ncbi.nlm.nih.gov/pubmed/33457348
http://dx.doi.org/10.4103/abr.abr_175_20
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author Ansari, Behnaz
Dorooshi, Gholamali
Lalehzar, Sahar Sadat
Taheri, Abolfazl
Meamar, Rokhsareh
author_facet Ansari, Behnaz
Dorooshi, Gholamali
Lalehzar, Sahar Sadat
Taheri, Abolfazl
Meamar, Rokhsareh
author_sort Ansari, Behnaz
collection PubMed
description A case is presented on a 40-year-old male with chronic lead poisoning with loss of consciousness, rhabdomyolysis, and acute renal failure after occupational exposure. Physical examination revealed generalized atrophy, tenderness, and swelling in the right limb and a decreased proximal muscle strength in the lower limb. A severe acute polyradiculoneuropathy in lower limbs documented by electromyography. All paraclinical tests were normal except increased blood lead level (75 μg/dl) and blue line in gum of the teeth. The patient was treated with penicillamine (500 mg q8 h) and pyridoxine (50 mg daily) for 8 months, only accessible drug in Iran. Force of patient's muscles in the proximal part of the lower limb was improved, and also the blood lead level reached to normal range. This is the first patient with rhabdomyolysis and muscle necrosis induced by lead poisoning.
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spelling pubmed-77928772021-01-15 Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning Ansari, Behnaz Dorooshi, Gholamali Lalehzar, Sahar Sadat Taheri, Abolfazl Meamar, Rokhsareh Adv Biomed Res Case Report A case is presented on a 40-year-old male with chronic lead poisoning with loss of consciousness, rhabdomyolysis, and acute renal failure after occupational exposure. Physical examination revealed generalized atrophy, tenderness, and swelling in the right limb and a decreased proximal muscle strength in the lower limb. A severe acute polyradiculoneuropathy in lower limbs documented by electromyography. All paraclinical tests were normal except increased blood lead level (75 μg/dl) and blue line in gum of the teeth. The patient was treated with penicillamine (500 mg q8 h) and pyridoxine (50 mg daily) for 8 months, only accessible drug in Iran. Force of patient's muscles in the proximal part of the lower limb was improved, and also the blood lead level reached to normal range. This is the first patient with rhabdomyolysis and muscle necrosis induced by lead poisoning. Wolters Kluwer - Medknow 2020-10-30 /pmc/articles/PMC7792877/ /pubmed/33457348 http://dx.doi.org/10.4103/abr.abr_175_20 Text en Copyright: © 2020 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Ansari, Behnaz
Dorooshi, Gholamali
Lalehzar, Sahar Sadat
Taheri, Abolfazl
Meamar, Rokhsareh
Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning
title Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning
title_full Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning
title_fullStr Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning
title_full_unstemmed Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning
title_short Rhabdomyolysis and Muscle Necrosis Induced By Lead Poisoning
title_sort rhabdomyolysis and muscle necrosis induced by lead poisoning
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792877/
https://www.ncbi.nlm.nih.gov/pubmed/33457348
http://dx.doi.org/10.4103/abr.abr_175_20
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