Cargando…

Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease. Gemcitabine (GEM) is used as the gold standard drug in PDAC treatment. However, due to its poor efficacy, it remains urgent to identify novel strategies to overcome resistance issues. In this context, an intense stroma r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Forciniti, Stefania, Dalla Pozza, Elisa, Greco, Maria Raffaella, Amaral Carvalho, Tiago Miguel, Rolando, Barbara, Ambrosini, Giulia, Carmona-Carmona, Cristian Andres, Pacchiana, Raffaella, Di Molfetta, Daria, Donadelli, Massimo, Arpicco, Silvia, Palmieri, Marta, Reshkin, Stephan Joel, Dando, Ilaria, Cardone, Rosa Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792955/ https://www.ncbi.nlm.nih.gov/pubmed/33375106 http://dx.doi.org/10.3390/ijms22010029

Ejemplares similares

Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic Review
por: Koltai, Tomas, et al.
Publicado: (2022)

3-Bromo-Isoxazoline Derivatives Inhibit GAPDH Enzyme in PDAC Cells Triggering Autophagy and Apoptotic Cell Death
por: Pacchiana, Raffaella, et al.
Publicado: (2022)

Divergent Roles of Mitochondria Dynamics in Pancreatic Ductal Adenocarcinoma
por: Carmona-Carmona, Cristian Andres, et al.
Publicado: (2022)

Mitochondrial Elongation and OPA1 Play Crucial Roles during the Stemness Acquisition Process in Pancreatic Ductal Adenocarcinoma
por: Carmona-Carmona, Cristian Andres, et al.
Publicado: (2022)

Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway
por: Greco, Maria Raffaella, et al.
Publicado: (2021)

Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches
por: Carvalho, Tiago M. A., et al.
Publicado: (2021)

ECM Composition Differentially Regulates Intracellular and Extracellular pH in Normal and Cancer Pancreatic Duct Epithelial Cells
por: Di Molfetta, Daria, et al.
Publicado: (2023)

Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells
por: Dando, Ilaria, et al.
Publicado: (2015)

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM Composition
por: Cannone, Stefania, et al.
Publicado: (2022)

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
por: Donadelli, M, et al.
Publicado: (2011)

Progressively De-Differentiated Pancreatic Cancer Cells Shift from Glycolysis to Oxidative Metabolism and Gain a Quiescent Stem State
por: Ambrosini, Giulia, et al.
Publicado: (2020)

New Insights into Metabolic Alterations and Mitochondria Re-Arrangements in Pancreatic Adenocarcinoma
por: Dando, Ilaria, et al.
Publicado: (2023)

Human Chorionic Gonadotropin-Mediated Induction of Breast Cancer Cell Proliferation and Differentiation
por: Dando, Ilaria, et al.
Publicado: (2021)

Mitochondrial Dynamics as Potential Modulators of Hormonal Therapy Effectiveness in Males
por: Errico, Andrea, et al.
Publicado: (2023)

Extracellular Matrix Collagen I Differentially Regulates the Metabolic Plasticity of Pancreatic Ductal Adenocarcinoma Parenchymal Cell and Cancer Stem Cell
por: Tavares-Valente, Diana, et al.
Publicado: (2023)

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells
por: Dando, I, et al.
Publicado: (2013)

Regulation of Autophagy by Nuclear GAPDH and Its Aggregates in Cancer and Neurodegenerative Disorders
por: Butera, Giovanna, et al.
Publicado: (2019)

Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells
por: Cordani, Marco, et al.
Publicado: (2020)

Redox Sensitive Cysteine Residues as Crucial Regulators of Wild-Type and Mutant p53 Isoforms
por: Butturini, Elena, et al.
Publicado: (2021)

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
por: Danzi, Federica, et al.
Publicado: (2023)

Delivery of Gemcitabine Prodrugs Employing Mesoporous Silica Nanoparticles
por: Malfanti, Alessio, et al.
Publicado: (2016)

Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer
por: Koltai, Tomas, et al.
Publicado: (2021)

The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela
por: Cardone, Rosa Angela, et al.
Publicado: (2019)

Role of Stromal Cells in Determining Tumor and Cancer Stem Cell Behaviors and Therapeutic Response
por: Reshkin, Stephan J., et al.
Publicado: (2020)

The rs1001179 SNP and CpG methylation regulate catalase expression in chronic lymphocytic leukemia
por: Galasso, Marilisa, et al.
Publicado: (2022)

Neuropsychiatric Consequences of Lipophilic Beta-Blockers
por: Cojocariu, Sabina Alexandra, et al.
Publicado: (2021)

Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells
por: Di Carlo, Claudia, et al.
Publicado: (2021)

Synergy Between Low Dose Metronomic Chemotherapy and the pH-Centered Approach Against Cancer
por: Koltai, Tomas, et al.
Publicado: (2019)

Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O(2ˉ)· production in cancer cells
por: Cordani, Marco, et al.
Publicado: (2018)

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy()
por: Cardone, Rosa Angela, et al.
Publicado: (2015)

Role of pH in Regulating Cancer Pyrimidine Synthesis
por: Alqahtani, Saad Saeed, et al.
Publicado: (2022)

Mitochondrial Features of Mouse Myoblasts Are Finely Tuned by Low Doses of Ozone: The Evidence In Vitro
por: Inguscio, Chiara Rita, et al.
Publicado: (2023)

Chemosensitization by lipophilic nitroimidazoles.
por: Twentyman, P. R., et al.
Publicado: (1983)

Hydrophilic or Lipophilic Statins?
por: Climent, Elisenda, et al.
Publicado: (2021)

NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains
por: Cardone, Rosa Angela, et al.
Publicado: (2012)

Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment
por: Altamura, Concetta, et al.
Publicado: (2021)

Pharmacokinetic models for lipophilic compounds.
por: Matthews, H B, et al.
Publicado: (1977)

Lipophilicity Studies on Thiosemicarbazide Derivatives
por: Paneth, Agata, et al.
Publicado: (2017)

Clinical Prognostic Factors in Patients With Metastatic Adrenocortical Carcinoma Treated With Second Line Gemcitabine Plus Capecitabine Chemotherapy
por: Grisanti, Salvatore, et al.
Publicado: (2021)

Iron Metabolism in Cancer Progression
por: Forciniti, Stefania, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j39mpvu24bqr7k2047j4b08grg