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Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy

SIMPLE SUMMARY: To assess the impact of thoracic (low) dose irradiation on pulmonary function changes after thoracic radiotherapy (RT) data of 62 patients were analyzed. There were several significant correlations between pulmonary function and dose parameters of the lung and heart, most of which re...

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Autores principales: Schröder, Christina, Buchali, André, Windisch, Paul, Vu, Erwin, Basler, Lucas, Zwahlen, Daniel R., Förster, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793060/
https://www.ncbi.nlm.nih.gov/pubmed/33374564
http://dx.doi.org/10.3390/cancers13010022
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author Schröder, Christina
Buchali, André
Windisch, Paul
Vu, Erwin
Basler, Lucas
Zwahlen, Daniel R.
Förster, Robert
author_facet Schröder, Christina
Buchali, André
Windisch, Paul
Vu, Erwin
Basler, Lucas
Zwahlen, Daniel R.
Förster, Robert
author_sort Schröder, Christina
collection PubMed
description SIMPLE SUMMARY: To assess the impact of thoracic (low) dose irradiation on pulmonary function changes after thoracic radiotherapy (RT) data of 62 patients were analyzed. There were several significant correlations between pulmonary function and dose parameters of the lung and heart, most of which remained significant in the multivariate analysis. ABSTRACT: Objective: To assess the impact of (low) dose irradiation to the lungs and heart on the incidence of pneumonitis and pulmonary function changes after thoracic radiotherapy (RT). Methods/Material: Data of 62 patients treated with curative thoracic radiotherapy were analyzed. Toxicity data and pulmonary function tests (PFTs) were obtained before RT and at 6 weeks, at 12 weeks, and at 6 months after RT. PFTs included ventilation (e.g., vital capacity) and diffusion parameters (e.g., diffusion capacity for carbon monoxide (DL(CO))). Dosimetric data of the lung and heart were extracted to assess the impact of dose on PFT changes and radiation pneumonitis (RP). Results: No statistically significant correlations between dose parameters and changes in ventilation parameters were found. There were statistically significant correlations between DL(CO) and low-dose parameters of the lungs (V(5Gy)–V(30Gy) (%)) and irradiation of the heart during the follow-up up to 6 months after RT, as well as a temporary correlation of the V(60Gy) (%) on the blood gas parameters at 12 weeks after RT. On multivariate analysis, both heart and lung parameters had a significant impact on DL(CO). There was no statistically significant influence of any patient or treatment-related (including dose parameters) factors on the incidence of ≥G2 pneumonitis. Conclusion: There seems to be a lasting impact of low dose irradiation to the lung as well as irradiation to the heart on the DL(CO) after thoracic radiotherapy. No influence on RP was found in this analysis.
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spelling pubmed-77930602021-01-09 Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy Schröder, Christina Buchali, André Windisch, Paul Vu, Erwin Basler, Lucas Zwahlen, Daniel R. Förster, Robert Cancers (Basel) Article SIMPLE SUMMARY: To assess the impact of thoracic (low) dose irradiation on pulmonary function changes after thoracic radiotherapy (RT) data of 62 patients were analyzed. There were several significant correlations between pulmonary function and dose parameters of the lung and heart, most of which remained significant in the multivariate analysis. ABSTRACT: Objective: To assess the impact of (low) dose irradiation to the lungs and heart on the incidence of pneumonitis and pulmonary function changes after thoracic radiotherapy (RT). Methods/Material: Data of 62 patients treated with curative thoracic radiotherapy were analyzed. Toxicity data and pulmonary function tests (PFTs) were obtained before RT and at 6 weeks, at 12 weeks, and at 6 months after RT. PFTs included ventilation (e.g., vital capacity) and diffusion parameters (e.g., diffusion capacity for carbon monoxide (DL(CO))). Dosimetric data of the lung and heart were extracted to assess the impact of dose on PFT changes and radiation pneumonitis (RP). Results: No statistically significant correlations between dose parameters and changes in ventilation parameters were found. There were statistically significant correlations between DL(CO) and low-dose parameters of the lungs (V(5Gy)–V(30Gy) (%)) and irradiation of the heart during the follow-up up to 6 months after RT, as well as a temporary correlation of the V(60Gy) (%) on the blood gas parameters at 12 weeks after RT. On multivariate analysis, both heart and lung parameters had a significant impact on DL(CO). There was no statistically significant influence of any patient or treatment-related (including dose parameters) factors on the incidence of ≥G2 pneumonitis. Conclusion: There seems to be a lasting impact of low dose irradiation to the lung as well as irradiation to the heart on the DL(CO) after thoracic radiotherapy. No influence on RP was found in this analysis. MDPI 2020-12-23 /pmc/articles/PMC7793060/ /pubmed/33374564 http://dx.doi.org/10.3390/cancers13010022 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schröder, Christina
Buchali, André
Windisch, Paul
Vu, Erwin
Basler, Lucas
Zwahlen, Daniel R.
Förster, Robert
Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy
title Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy
title_full Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy
title_fullStr Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy
title_full_unstemmed Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy
title_short Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy
title_sort impact of low-dose irradiation of the lung and heart on toxicity and pulmonary function parameters after thoracic radiotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793060/
https://www.ncbi.nlm.nih.gov/pubmed/33374564
http://dx.doi.org/10.3390/cancers13010022
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