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NUDT15 genotyping during azathioprine treatment in patients with inflammatory bowel disease: implications for a dose-optimization strategy

BACKGROUND: NUDT15 R139C is an Asian-prevalent genetic variant related to azathioprine (AZA) intolerance in patients with inflammatory bowel disease (IBD). However, it remains unclear how to utilize the genotyping results to improve the step-up dosing strategy with an already low starting dose in As...

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Detalles Bibliográficos
Autores principales:	Xu, Ye, Qiao, Yu-Qi, Li, Han-Yang, Zhou, Mi, Cai, Chen-Wen, Shen, Jun, Ran, Zhi-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793196/ https://www.ncbi.nlm.nih.gov/pubmed/33442476 http://dx.doi.org/10.1093/gastro/goaa021

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