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Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis
An internal carotid artery (ICA) stenosis can potentially decrease the perfusion pressure to the brain. In this study, computational fluid dynamics (CFD) was used to study if there was a hemispheric pressure laterality between the contra- and ipsilateral middle cerebral artery (MCA) in patients with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793245/ https://www.ncbi.nlm.nih.gov/pubmed/33417614 http://dx.doi.org/10.1371/journal.pone.0245337 |
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author | Holmgren, Madelene Støverud, Karen-Helene Zarrinkoob, Laleh Wåhlin, Anders Malm, Jan Eklund, Anders |
author_facet | Holmgren, Madelene Støverud, Karen-Helene Zarrinkoob, Laleh Wåhlin, Anders Malm, Jan Eklund, Anders |
author_sort | Holmgren, Madelene |
collection | PubMed |
description | An internal carotid artery (ICA) stenosis can potentially decrease the perfusion pressure to the brain. In this study, computational fluid dynamics (CFD) was used to study if there was a hemispheric pressure laterality between the contra- and ipsilateral middle cerebral artery (MCA) in patients with a symptomatic ICA stenosis. We further investigated if this MCA pressure laterality (ΔP(MCA)) was related to the hemispheric flow laterality (ΔQ) in the anterior circulation, i.e., ICA, proximal MCA and the proximal anterior cerebral artery (ACA). Twenty-eight patients (73±6 years, range 59–80 years, 21 men) with symptomatic ICA stenosis were included. Flow rates were measured using 4D flow MRI data (PC-VIPR) and vessel geometries were obtained from computed tomography angiography. The ΔP(MCA) was calculated from CFD, where patient-specific flow rates were applied at all input- and output boundaries. The ΔP(MCA) between the contra- and ipsilateral side was 6.4±8.3 mmHg (p<0.001) (median 3.9 mmHg, range -1.3 to 31.9 mmHg). There was a linear correlation between the ΔP(MCA) and ΔQ(ICA) (r = 0.85, p<0.001) and ΔQ(ACA) (r = 0.71, p<0.001), respectively. The correlation to ΔQ(MCA) was weaker (r = 0.47, p = 0.011). In conclusion, the MCA pressure laterality obtained with CFD, is a promising physiological biomarker that can grade the hemodynamic disturbance in patients with a symptomatic ICA stenosis. |
format | Online Article Text |
id | pubmed-7793245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77932452021-01-27 Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis Holmgren, Madelene Støverud, Karen-Helene Zarrinkoob, Laleh Wåhlin, Anders Malm, Jan Eklund, Anders PLoS One Research Article An internal carotid artery (ICA) stenosis can potentially decrease the perfusion pressure to the brain. In this study, computational fluid dynamics (CFD) was used to study if there was a hemispheric pressure laterality between the contra- and ipsilateral middle cerebral artery (MCA) in patients with a symptomatic ICA stenosis. We further investigated if this MCA pressure laterality (ΔP(MCA)) was related to the hemispheric flow laterality (ΔQ) in the anterior circulation, i.e., ICA, proximal MCA and the proximal anterior cerebral artery (ACA). Twenty-eight patients (73±6 years, range 59–80 years, 21 men) with symptomatic ICA stenosis were included. Flow rates were measured using 4D flow MRI data (PC-VIPR) and vessel geometries were obtained from computed tomography angiography. The ΔP(MCA) was calculated from CFD, where patient-specific flow rates were applied at all input- and output boundaries. The ΔP(MCA) between the contra- and ipsilateral side was 6.4±8.3 mmHg (p<0.001) (median 3.9 mmHg, range -1.3 to 31.9 mmHg). There was a linear correlation between the ΔP(MCA) and ΔQ(ICA) (r = 0.85, p<0.001) and ΔQ(ACA) (r = 0.71, p<0.001), respectively. The correlation to ΔQ(MCA) was weaker (r = 0.47, p = 0.011). In conclusion, the MCA pressure laterality obtained with CFD, is a promising physiological biomarker that can grade the hemodynamic disturbance in patients with a symptomatic ICA stenosis. Public Library of Science 2021-01-08 /pmc/articles/PMC7793245/ /pubmed/33417614 http://dx.doi.org/10.1371/journal.pone.0245337 Text en © 2021 Holmgren et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Holmgren, Madelene Støverud, Karen-Helene Zarrinkoob, Laleh Wåhlin, Anders Malm, Jan Eklund, Anders Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis |
title | Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis |
title_full | Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis |
title_fullStr | Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis |
title_full_unstemmed | Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis |
title_short | Middle cerebral artery pressure laterality in patients with symptomatic ICA stenosis |
title_sort | middle cerebral artery pressure laterality in patients with symptomatic ica stenosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793245/ https://www.ncbi.nlm.nih.gov/pubmed/33417614 http://dx.doi.org/10.1371/journal.pone.0245337 |
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