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The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma

HERV-H LTR –associating 2 (HHLA2) is a recently discovered member of the B7-family of immune checkpoint molecules that is overexpressed in several types of cancer. The aim of the present study was to investigate the expression of HHLA2 in cervical adenocarcinoma (AC) and the relationship between its...

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Autores principales: Byun, Jung Mi, Cho, Hwa Jin, Park, Ha Young, Lee, Dae Sim, Choi, In Hak, Kim, Young Nam, Jeong, Chul Hoi, Kim, Da Hyun, Hwa Im, Do, Min, Byoung Jin, Lee, Kyung Bok, Sung, Moon Su, Jeong, Dae Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793359/
https://www.ncbi.nlm.nih.gov/pubmed/33429737
http://dx.doi.org/10.1097/MD.0000000000023691
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author Byun, Jung Mi
Cho, Hwa Jin
Park, Ha Young
Lee, Dae Sim
Choi, In Hak
Kim, Young Nam
Jeong, Chul Hoi
Kim, Da Hyun
Hwa Im, Do
Min, Byoung Jin
Lee, Kyung Bok
Sung, Moon Su
Jeong, Dae Hoon
author_facet Byun, Jung Mi
Cho, Hwa Jin
Park, Ha Young
Lee, Dae Sim
Choi, In Hak
Kim, Young Nam
Jeong, Chul Hoi
Kim, Da Hyun
Hwa Im, Do
Min, Byoung Jin
Lee, Kyung Bok
Sung, Moon Su
Jeong, Dae Hoon
author_sort Byun, Jung Mi
collection PubMed
description HERV-H LTR –associating 2 (HHLA2) is a recently discovered member of the B7-family of immune checkpoint molecules that is overexpressed in several types of cancer. The aim of the present study was to investigate the expression of HHLA2 in cervical adenocarcinoma (AC) and the relationship between its expression and clinicopathological factors to assess its use as a potential marker for AC prognosis. This study included 76 patients diagnosed with cervical AC. Their resected specimens were obtained and a tissue microarray was constructed. Expression of HHLA2 was detected by the immunohistochemistry. Based on the follow-up data, correlation of HHLA2 expression and clinicopathological features, including overall survival (OS) and disease-free survival, was evaluated. Furthermore, we investigated the correlation between the expression of HHLA2 and programmed death ligand 1 (PD-L1). A total of 76 cases of invasive cervical AC were evaluated. High HHLA2 expression was detected in 62 cases (81.6%) and low HHLA2 expression was presented in 14 cases (18.4%). HHLA2 expression showed a significant negative correlation with lymph node metastasis (P = .011). Disease free survival was 75.0% and 49.0% in high-expression and the low expression group, respectively (P = .057). Although there was no statistical significance, an improved OS was observed in the high expression group (83.1% vs 64.9%, P = .479). Further, the expression of HHLA2 and PD-L1 correlated positively (P = .005). Thus, an improved OS was observed in the PD-L1 expression group (90.7% vs 66.2%, P = .037). High expression of HHLA2 is related to tumor progression and prognosis in patients with cervical AC. Therefore, HHLA2 may be a potential biomarker for predicting prognosis of cervical AC.
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spelling pubmed-77933592021-01-11 The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma Byun, Jung Mi Cho, Hwa Jin Park, Ha Young Lee, Dae Sim Choi, In Hak Kim, Young Nam Jeong, Chul Hoi Kim, Da Hyun Hwa Im, Do Min, Byoung Jin Lee, Kyung Bok Sung, Moon Su Jeong, Dae Hoon Medicine (Baltimore) 5600 HERV-H LTR –associating 2 (HHLA2) is a recently discovered member of the B7-family of immune checkpoint molecules that is overexpressed in several types of cancer. The aim of the present study was to investigate the expression of HHLA2 in cervical adenocarcinoma (AC) and the relationship between its expression and clinicopathological factors to assess its use as a potential marker for AC prognosis. This study included 76 patients diagnosed with cervical AC. Their resected specimens were obtained and a tissue microarray was constructed. Expression of HHLA2 was detected by the immunohistochemistry. Based on the follow-up data, correlation of HHLA2 expression and clinicopathological features, including overall survival (OS) and disease-free survival, was evaluated. Furthermore, we investigated the correlation between the expression of HHLA2 and programmed death ligand 1 (PD-L1). A total of 76 cases of invasive cervical AC were evaluated. High HHLA2 expression was detected in 62 cases (81.6%) and low HHLA2 expression was presented in 14 cases (18.4%). HHLA2 expression showed a significant negative correlation with lymph node metastasis (P = .011). Disease free survival was 75.0% and 49.0% in high-expression and the low expression group, respectively (P = .057). Although there was no statistical significance, an improved OS was observed in the high expression group (83.1% vs 64.9%, P = .479). Further, the expression of HHLA2 and PD-L1 correlated positively (P = .005). Thus, an improved OS was observed in the PD-L1 expression group (90.7% vs 66.2%, P = .037). High expression of HHLA2 is related to tumor progression and prognosis in patients with cervical AC. Therefore, HHLA2 may be a potential biomarker for predicting prognosis of cervical AC. Lippincott Williams & Wilkins 2021-01-08 /pmc/articles/PMC7793359/ /pubmed/33429737 http://dx.doi.org/10.1097/MD.0000000000023691 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5600
Byun, Jung Mi
Cho, Hwa Jin
Park, Ha Young
Lee, Dae Sim
Choi, In Hak
Kim, Young Nam
Jeong, Chul Hoi
Kim, Da Hyun
Hwa Im, Do
Min, Byoung Jin
Lee, Kyung Bok
Sung, Moon Su
Jeong, Dae Hoon
The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma
title The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma
title_full The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma
title_fullStr The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma
title_full_unstemmed The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma
title_short The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma
title_sort clinical significance of herv-h ltr –associating 2 expression in cervical adenocarcinoma
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793359/
https://www.ncbi.nlm.nih.gov/pubmed/33429737
http://dx.doi.org/10.1097/MD.0000000000023691
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