Cargando…
The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma
HERV-H LTR –associating 2 (HHLA2) is a recently discovered member of the B7-family of immune checkpoint molecules that is overexpressed in several types of cancer. The aim of the present study was to investigate the expression of HHLA2 in cervical adenocarcinoma (AC) and the relationship between its...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793359/ https://www.ncbi.nlm.nih.gov/pubmed/33429737 http://dx.doi.org/10.1097/MD.0000000000023691 |
_version_ | 1783633972576649216 |
---|---|
author | Byun, Jung Mi Cho, Hwa Jin Park, Ha Young Lee, Dae Sim Choi, In Hak Kim, Young Nam Jeong, Chul Hoi Kim, Da Hyun Hwa Im, Do Min, Byoung Jin Lee, Kyung Bok Sung, Moon Su Jeong, Dae Hoon |
author_facet | Byun, Jung Mi Cho, Hwa Jin Park, Ha Young Lee, Dae Sim Choi, In Hak Kim, Young Nam Jeong, Chul Hoi Kim, Da Hyun Hwa Im, Do Min, Byoung Jin Lee, Kyung Bok Sung, Moon Su Jeong, Dae Hoon |
author_sort | Byun, Jung Mi |
collection | PubMed |
description | HERV-H LTR –associating 2 (HHLA2) is a recently discovered member of the B7-family of immune checkpoint molecules that is overexpressed in several types of cancer. The aim of the present study was to investigate the expression of HHLA2 in cervical adenocarcinoma (AC) and the relationship between its expression and clinicopathological factors to assess its use as a potential marker for AC prognosis. This study included 76 patients diagnosed with cervical AC. Their resected specimens were obtained and a tissue microarray was constructed. Expression of HHLA2 was detected by the immunohistochemistry. Based on the follow-up data, correlation of HHLA2 expression and clinicopathological features, including overall survival (OS) and disease-free survival, was evaluated. Furthermore, we investigated the correlation between the expression of HHLA2 and programmed death ligand 1 (PD-L1). A total of 76 cases of invasive cervical AC were evaluated. High HHLA2 expression was detected in 62 cases (81.6%) and low HHLA2 expression was presented in 14 cases (18.4%). HHLA2 expression showed a significant negative correlation with lymph node metastasis (P = .011). Disease free survival was 75.0% and 49.0% in high-expression and the low expression group, respectively (P = .057). Although there was no statistical significance, an improved OS was observed in the high expression group (83.1% vs 64.9%, P = .479). Further, the expression of HHLA2 and PD-L1 correlated positively (P = .005). Thus, an improved OS was observed in the PD-L1 expression group (90.7% vs 66.2%, P = .037). High expression of HHLA2 is related to tumor progression and prognosis in patients with cervical AC. Therefore, HHLA2 may be a potential biomarker for predicting prognosis of cervical AC. |
format | Online Article Text |
id | pubmed-7793359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-77933592021-01-11 The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma Byun, Jung Mi Cho, Hwa Jin Park, Ha Young Lee, Dae Sim Choi, In Hak Kim, Young Nam Jeong, Chul Hoi Kim, Da Hyun Hwa Im, Do Min, Byoung Jin Lee, Kyung Bok Sung, Moon Su Jeong, Dae Hoon Medicine (Baltimore) 5600 HERV-H LTR –associating 2 (HHLA2) is a recently discovered member of the B7-family of immune checkpoint molecules that is overexpressed in several types of cancer. The aim of the present study was to investigate the expression of HHLA2 in cervical adenocarcinoma (AC) and the relationship between its expression and clinicopathological factors to assess its use as a potential marker for AC prognosis. This study included 76 patients diagnosed with cervical AC. Their resected specimens were obtained and a tissue microarray was constructed. Expression of HHLA2 was detected by the immunohistochemistry. Based on the follow-up data, correlation of HHLA2 expression and clinicopathological features, including overall survival (OS) and disease-free survival, was evaluated. Furthermore, we investigated the correlation between the expression of HHLA2 and programmed death ligand 1 (PD-L1). A total of 76 cases of invasive cervical AC were evaluated. High HHLA2 expression was detected in 62 cases (81.6%) and low HHLA2 expression was presented in 14 cases (18.4%). HHLA2 expression showed a significant negative correlation with lymph node metastasis (P = .011). Disease free survival was 75.0% and 49.0% in high-expression and the low expression group, respectively (P = .057). Although there was no statistical significance, an improved OS was observed in the high expression group (83.1% vs 64.9%, P = .479). Further, the expression of HHLA2 and PD-L1 correlated positively (P = .005). Thus, an improved OS was observed in the PD-L1 expression group (90.7% vs 66.2%, P = .037). High expression of HHLA2 is related to tumor progression and prognosis in patients with cervical AC. Therefore, HHLA2 may be a potential biomarker for predicting prognosis of cervical AC. Lippincott Williams & Wilkins 2021-01-08 /pmc/articles/PMC7793359/ /pubmed/33429737 http://dx.doi.org/10.1097/MD.0000000000023691 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5600 Byun, Jung Mi Cho, Hwa Jin Park, Ha Young Lee, Dae Sim Choi, In Hak Kim, Young Nam Jeong, Chul Hoi Kim, Da Hyun Hwa Im, Do Min, Byoung Jin Lee, Kyung Bok Sung, Moon Su Jeong, Dae Hoon The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma |
title | The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma |
title_full | The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma |
title_fullStr | The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma |
title_full_unstemmed | The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma |
title_short | The clinical significance of HERV-H LTR –associating 2 expression in cervical adenocarcinoma |
title_sort | clinical significance of herv-h ltr –associating 2 expression in cervical adenocarcinoma |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793359/ https://www.ncbi.nlm.nih.gov/pubmed/33429737 http://dx.doi.org/10.1097/MD.0000000000023691 |
work_keys_str_mv | AT byunjungmi theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT chohwajin theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT parkhayoung theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT leedaesim theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT choiinhak theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT kimyoungnam theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT jeongchulhoi theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT kimdahyun theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT hwaimdo theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT minbyoungjin theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT leekyungbok theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT sungmoonsu theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT jeongdaehoon theclinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT byunjungmi clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT chohwajin clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT parkhayoung clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT leedaesim clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT choiinhak clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT kimyoungnam clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT jeongchulhoi clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT kimdahyun clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT hwaimdo clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT minbyoungjin clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT leekyungbok clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT sungmoonsu clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma AT jeongdaehoon clinicalsignificanceofhervhltrassociating2expressionincervicaladenocarcinoma |