TRIM26 is a critical host factor for HCV replication and contributes to host tropism

Hepatitis C virus (HCV) remains a major human pathogen that requires better understanding of virus-host interactions. In this study, we performed a genome-wide CRISPR-Cas9 screening and identified TRIM26, an E3 ligase, as a critical HCV host factor. Deficiency of TRIM26 specifically impairs HCV geno...

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Detalles Bibliográficos
Autores principales: Liang, Yisha, Zhang, Guigen, Li, Qiheng, Han, Lin, Hu, Xiaoyou, Guo, Yu, Tao, Wanyin, Zhao, Xiaomin, Guo, Mingzhe, Gan, Tianyu, Tong, Yimin, Xu, Yongfen, Zhou, Zhuo, Ding, Qiang, Wei, Wensheng, Zhong, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793585/
https://www.ncbi.nlm.nih.gov/pubmed/33523994
http://dx.doi.org/10.1126/sciadv.abd9732

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