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Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis
Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793643/ https://www.ncbi.nlm.nih.gov/pubmed/33424580 http://dx.doi.org/10.3389/fnagi.2020.603854 |
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author | Cui, Lei Hou, Na-Na Wu, Hong-Mei Zuo, Xiang Lian, Yi-Zhi Zhang, Chao-Nan Wang, Zhen-Feng Zhang, Xiong Zhu, Jian-Hong |
author_facet | Cui, Lei Hou, Na-Na Wu, Hong-Mei Zuo, Xiang Lian, Yi-Zhi Zhang, Chao-Nan Wang, Zhen-Feng Zhang, Xiong Zhu, Jian-Hong |
author_sort | Cui, Lei |
collection | PubMed |
description | Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified via a systematic database search from 1985 to 2018. Meta-analysis, local polynomial regression and autoregressive integrated moving average model were used for analyses. Results: A total of 99 studies were included in the study with populations of 385,312 and 227,228, respectively for AD and PD. The overall prevalence of AD and PD following age standardization was 3.20% [95% confidence interval (CI) = 3.17–3.23] and 1.06% (95% CI = 1.02–1.10), respectively in individuals over 60 years old. The rates increased drastically for every 10-years increment of age. The yearly prevalence of AD was predicted to increase from 3.81 to 6.17% in the next 5 years. Significant differences were observed between genders [male to female odds ratio (OR) for AD = 0.57, 95% CI = 0.51–0.64; OR for PD = 1.25, 95% CI = 1.06–1.46], and between education levels (Illiterate to non-illiterate OR for AD = 2.99, 95% CI = 2.38–3.75), but not between urban and rural settings. Conclusion: Our results provide an updated insight into the epidemiology of AD and PD in China and their associated rates and ratios. The findings may facilitate China policy makers and health professionals mitigate the related health issues. |
format | Online Article Text |
id | pubmed-7793643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77936432021-01-09 Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis Cui, Lei Hou, Na-Na Wu, Hong-Mei Zuo, Xiang Lian, Yi-Zhi Zhang, Chao-Nan Wang, Zhen-Feng Zhang, Xiong Zhu, Jian-Hong Front Aging Neurosci Neuroscience Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Methods: Studies that reported the prevalence of AD and PD in China were identified via a systematic database search from 1985 to 2018. Meta-analysis, local polynomial regression and autoregressive integrated moving average model were used for analyses. Results: A total of 99 studies were included in the study with populations of 385,312 and 227,228, respectively for AD and PD. The overall prevalence of AD and PD following age standardization was 3.20% [95% confidence interval (CI) = 3.17–3.23] and 1.06% (95% CI = 1.02–1.10), respectively in individuals over 60 years old. The rates increased drastically for every 10-years increment of age. The yearly prevalence of AD was predicted to increase from 3.81 to 6.17% in the next 5 years. Significant differences were observed between genders [male to female odds ratio (OR) for AD = 0.57, 95% CI = 0.51–0.64; OR for PD = 1.25, 95% CI = 1.06–1.46], and between education levels (Illiterate to non-illiterate OR for AD = 2.99, 95% CI = 2.38–3.75), but not between urban and rural settings. Conclusion: Our results provide an updated insight into the epidemiology of AD and PD in China and their associated rates and ratios. The findings may facilitate China policy makers and health professionals mitigate the related health issues. Frontiers Media S.A. 2020-12-21 /pmc/articles/PMC7793643/ /pubmed/33424580 http://dx.doi.org/10.3389/fnagi.2020.603854 Text en Copyright © 2020 Cui, Hou, Wu, Zuo, Lian, Zhang, Wang, Zhang and Zhu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Cui, Lei Hou, Na-Na Wu, Hong-Mei Zuo, Xiang Lian, Yi-Zhi Zhang, Chao-Nan Wang, Zhen-Feng Zhang, Xiong Zhu, Jian-Hong Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis |
title | Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis |
title_full | Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis |
title_fullStr | Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis |
title_full_unstemmed | Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis |
title_short | Prevalence of Alzheimer's Disease and Parkinson's Disease in China: An Updated Systematical Analysis |
title_sort | prevalence of alzheimer's disease and parkinson's disease in china: an updated systematical analysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793643/ https://www.ncbi.nlm.nih.gov/pubmed/33424580 http://dx.doi.org/10.3389/fnagi.2020.603854 |
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