Cargando…

Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of Chondrosarcoma

Purpose: Chondrosarcomas are a group of cartilaginous malignant neoplasms characterized by the deposition of chondrogenic extracellular matrix. Surgical resection is currently the only curative treatment option, due to their high resistance to conventional chemotherapy and radiotherapy. Novel therap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palubeckaitė, Ieva, Venneker, Sanne, Briaire-de Bruijn, Inge H., van den Akker, Brendy E., Krol, Augustinus D., Gelderblom, Hans, Bovée, Judith V. M. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793672/ https://www.ncbi.nlm.nih.gov/pubmed/33425984 http://dx.doi.org/10.3389/fmolb.2020.566291

Ejemplares similares

Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma
por: Venneker, Sanne, et al.
Publicado: (2020)

Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes
por: de Jong, Yvonne, et al.
Publicado: (2019)

IDH Mutations in Chondrosarcoma: Case Closed or Not?
por: Venneker, Sanne, et al.
Publicado: (2023)

Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression
por: Franceschini, Natasja, et al.
Publicado: (2021)

Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status
por: Venneker, Sanne, et al.
Publicado: (2019)

A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival
por: de Jong, Yvonne, et al.
Publicado: (2019)

Histone Deacetylase Inhibitors as a Therapeutic Strategy to Eliminate Neoplastic “Stromal” Cells from Giant Cell Tumors of Bone
por: Venneker, Sanne, et al.
Publicado: (2022)

SUMOylation Is Associated with Aggressive Behavior in Chondrosarcoma of Bone
por: Kroonen, Jessie S., et al.
Publicado: (2021)

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors
por: Boeuf, Stephane, et al.
Publicado: (2012)

A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic target
por: Franceschini, Natasja, et al.
Publicado: (2021)

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma
por: He, Lile, et al.
Publicado: (2019)

Crystalline Sponge Method by Three-Dimensional Electron Diffraction
por: Chen, Pohua, et al.
Publicado: (2022)

Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma
por: de Jong, Yvonne, et al.
Publicado: (2018)

Comprehensive analysis of published studies involving systemic treatment for chondrosarcoma of bone between 2000 and 2013
por: van Maldegem, Annemiek M, et al.
Publicado: (2014)

Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells
por: van Oosterwijk, J G, et al.
Publicado: (2013)

The Sequence and Three-Dimensional Structure Characterization of Snake Venom Phospholipases B
por: Ullah, Anwar, et al.
Publicado: (2020)

No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone
por: Peterse, Elisabeth F. P., et al.
Publicado: (2016)

Histological response to radiotherapy is an early event in myxoid liposarcoma
por: Lam, Suk Wai, et al.
Publicado: (2023)

Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer
por: Pinto, Catarina I. G., et al.
Publicado: (2020)

A Three-Dimensional Organoid Model of Primary Breast Cancer to Investigate the Effects of Oncolytic Virotherapy
por: Carter, Mary E., et al.
Publicado: (2022)

Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation
por: Peterse, Elisabeth F. P., et al.
Publicado: (2018)

Reconstruction of Three-Dimensional Conformations of Bacterial ClpB from High-Speed Atomic-Force-Microscopy Images
por: Dasgupta, Bhaskar, et al.
Publicado: (2021)

Three-Dimensional Model of Sub-Plasmalemmal Ca(2+) Microdomains Evoked by T Cell Receptor/CD3 Complex Stimulation
por: Gil, Diana, et al.
Publicado: (2022)

Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo
por: Meijer, Danielle, et al.
Publicado: (2011)

IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas
por: Cleven, Arjen H. G., et al.
Publicado: (2017)

Using Dimensionality Reduction to Analyze Protein Trajectories
por: Tribello, Gareth A., et al.
Publicado: (2019)

Two-dimensional measurements of receptor-ligand interactions
por: Zheng, Songjie, et al.
Publicado: (2023)

Optimal Experimental Design Based on Two-Dimensional Likelihood Profiles
por: Litwin, Tim, et al.
Publicado: (2022)

Supported Lipid Bilayers and the Study of Two-Dimensional Binding Kinetics
por: Dam, Tommy, et al.
Publicado: (2022)

Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone
por: van Oosterwijk, Jolieke G, et al.
Publicado: (2012)

A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals
por: Parthasarathy, Anutthaman, et al.
Publicado: (2018)

Multi-Dimensional Display of Wang’s Lymph Node Map Using Virtual Bronchoscopic Navigation System
por: Lan, Fen, et al.
Publicado: (2021)

Nascent Folding of Proteins Across the Three Domains of Life
por: Chwastyk, Mateusz, et al.
Publicado: (2021)

Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst
por: Ong, Sheena L.M., et al.
Publicado: (2021)

Identification of microRNA editing sites in three subtypes of leukemia
por: Xie, Wenping, et al.
Publicado: (2022)

Practical Protocols for Efficient Sampling of Kinase-Inhibitor Binding Pathways Using Two-Dimensional Replica-Exchange Molecular Dynamics
por: Shinobu, Ai, et al.
Publicado: (2022)

The Integrative Analysis Identifies Three Cancer Subtypes and Stemness Features in Cutaneous Melanoma
por: Wang, Xiaoran, et al.
Publicado: (2021)

Three Month Follow-Up of Patients With COVID-19 Pneumonia Complicated by Pulmonary Embolism
por: Calabrese, Cecilia, et al.
Publicado: (2022)

Targeting survivin as a potential new treatment for chondrosarcoma of bone
por: de Jong, Y, et al.
Publicado: (2016)

A Three-Gene Peripheral Blood Potential Diagnosis Signature for Acute Rejection in Renal Transplantation
por: Wang, Yicun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_feq86tai5ruica55gqck0r622b