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Cancer Omics in Africa: Present and Prospects

During the last century, cancer biology has been arguably one of the most investigated research fields. To gain deeper insight into cancer mechanisms, scientists have been attempting to integrate multi omics data in cancer research. Cancer genomics, transcriptomics, metabolomics, proteomics, and meta...

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Autores principales: El Jaddaoui, Islam, Allali, Imane, Sehli, Sofia, Ouldim, Karim, Hamdi, Salsabil, Al Idrissi, Najib, Nejjari, Chakib, Amzazi, Saaïd, Bakri, Youssef, Ghazal, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793679/
https://www.ncbi.nlm.nih.gov/pubmed/33425763
http://dx.doi.org/10.3389/fonc.2020.606428
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author El Jaddaoui, Islam
Allali, Imane
Sehli, Sofia
Ouldim, Karim
Hamdi, Salsabil
Al Idrissi, Najib
Nejjari, Chakib
Amzazi, Saaïd
Bakri, Youssef
Ghazal, Hassan
author_facet El Jaddaoui, Islam
Allali, Imane
Sehli, Sofia
Ouldim, Karim
Hamdi, Salsabil
Al Idrissi, Najib
Nejjari, Chakib
Amzazi, Saaïd
Bakri, Youssef
Ghazal, Hassan
author_sort El Jaddaoui, Islam
collection PubMed
description During the last century, cancer biology has been arguably one of the most investigated research fields. To gain deeper insight into cancer mechanisms, scientists have been attempting to integrate multi omics data in cancer research. Cancer genomics, transcriptomics, metabolomics, proteomics, and metagenomics are the main multi omics strategies used currently in the diagnosis, prognosis, treatment, and biomarker discovery in cancer. In this review, we describe the use of different multi omics strategies in cancer research in the African continent and discuss the main challenges facing the implementation of these approaches in African countries such as the lack of training programs in bioinformatics in general and omics strategies in particular and suggest paths to address deficiencies. As a way forward, we advocate for the establishment of an “African Cancer Genomics Consortium” to promote intracontinental collaborative projects and enhance engagement in research activities that address indigenous aspects for cancer precision medicine.
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spelling pubmed-77936792021-01-09 Cancer Omics in Africa: Present and Prospects El Jaddaoui, Islam Allali, Imane Sehli, Sofia Ouldim, Karim Hamdi, Salsabil Al Idrissi, Najib Nejjari, Chakib Amzazi, Saaïd Bakri, Youssef Ghazal, Hassan Front Oncol Oncology During the last century, cancer biology has been arguably one of the most investigated research fields. To gain deeper insight into cancer mechanisms, scientists have been attempting to integrate multi omics data in cancer research. Cancer genomics, transcriptomics, metabolomics, proteomics, and metagenomics are the main multi omics strategies used currently in the diagnosis, prognosis, treatment, and biomarker discovery in cancer. In this review, we describe the use of different multi omics strategies in cancer research in the African continent and discuss the main challenges facing the implementation of these approaches in African countries such as the lack of training programs in bioinformatics in general and omics strategies in particular and suggest paths to address deficiencies. As a way forward, we advocate for the establishment of an “African Cancer Genomics Consortium” to promote intracontinental collaborative projects and enhance engagement in research activities that address indigenous aspects for cancer precision medicine. Frontiers Media S.A. 2020-12-14 /pmc/articles/PMC7793679/ /pubmed/33425763 http://dx.doi.org/10.3389/fonc.2020.606428 Text en Copyright © 2020 El Jaddaoui, Allali, Sehli, Ouldim, Hamdi, Al Idrissi, Nejjari, Amzazi, Bakri and Ghazal http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
El Jaddaoui, Islam
Allali, Imane
Sehli, Sofia
Ouldim, Karim
Hamdi, Salsabil
Al Idrissi, Najib
Nejjari, Chakib
Amzazi, Saaïd
Bakri, Youssef
Ghazal, Hassan
Cancer Omics in Africa: Present and Prospects
title Cancer Omics in Africa: Present and Prospects
title_full Cancer Omics in Africa: Present and Prospects
title_fullStr Cancer Omics in Africa: Present and Prospects
title_full_unstemmed Cancer Omics in Africa: Present and Prospects
title_short Cancer Omics in Africa: Present and Prospects
title_sort cancer omics in africa: present and prospects
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793679/
https://www.ncbi.nlm.nih.gov/pubmed/33425763
http://dx.doi.org/10.3389/fonc.2020.606428
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