Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment

MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immu...

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Autores principales: McMurray, Jeremy C., May, Joseph W., Cunningham, Madeleine W., Jones, Olcay Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793714/
https://www.ncbi.nlm.nih.gov/pubmed/33425823
http://dx.doi.org/10.3389/fped.2020.626182
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author McMurray, Jeremy C.
May, Joseph W.
Cunningham, Madeleine W.
Jones, Olcay Y.
author_facet McMurray, Jeremy C.
May, Joseph W.
Cunningham, Madeleine W.
Jones, Olcay Y.
author_sort McMurray, Jeremy C.
collection PubMed
description MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.
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spelling pubmed-77937142021-01-09 Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment McMurray, Jeremy C. May, Joseph W. Cunningham, Madeleine W. Jones, Olcay Y. Front Pediatr Pediatrics MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever. Frontiers Media S.A. 2020-12-16 /pmc/articles/PMC7793714/ /pubmed/33425823 http://dx.doi.org/10.3389/fped.2020.626182 Text en Copyright © 2020 McMurray, May, Cunningham and Jones. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
McMurray, Jeremy C.
May, Joseph W.
Cunningham, Madeleine W.
Jones, Olcay Y.
Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment
title Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment
title_full Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment
title_fullStr Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment
title_full_unstemmed Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment
title_short Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment
title_sort multisystem inflammatory syndrome in children (mis-c), a post-viral myocarditis and systemic vasculitis—a critical review of its pathogenesis and treatment
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793714/
https://www.ncbi.nlm.nih.gov/pubmed/33425823
http://dx.doi.org/10.3389/fped.2020.626182
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