The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target

This article reviews the pathogenetic role of the complement system in myocardial infarction reperfusion injury. The complement activation pathways involved in myocardial tissue injury are identified, as are the complement-derived effector molecules. The results of past anti-complement therapies are...

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Detalles Bibliográficos
Autor principal: Vogel, Carl-Wilhelm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793727/
https://www.ncbi.nlm.nih.gov/pubmed/33425913
http://dx.doi.org/10.3389/fcell.2020.606407
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author Vogel, Carl-Wilhelm
author_facet Vogel, Carl-Wilhelm
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description This article reviews the pathogenetic role of the complement system in myocardial infarction reperfusion injury. The complement activation pathways involved in myocardial tissue injury are identified, as are the complement-derived effector molecules. The results of past anti-complement therapies are reviewed; as the more recent therapeutic concept of complement depletion with humanized CVF described.
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spelling pubmed-77937272021-01-09 The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target Vogel, Carl-Wilhelm Front Cell Dev Biol Cell and Developmental Biology This article reviews the pathogenetic role of the complement system in myocardial infarction reperfusion injury. The complement activation pathways involved in myocardial tissue injury are identified, as are the complement-derived effector molecules. The results of past anti-complement therapies are reviewed; as the more recent therapeutic concept of complement depletion with humanized CVF described. Frontiers Media S.A. 2020-12-23 /pmc/articles/PMC7793727/ /pubmed/33425913 http://dx.doi.org/10.3389/fcell.2020.606407 Text en Copyright © 2020 Vogel. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Vogel, Carl-Wilhelm
The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target
title The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target
title_full The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target
title_fullStr The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target
title_full_unstemmed The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target
title_short The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target
title_sort role of complement in myocardial infarction reperfusion injury: an underappreciated therapeutic target
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793727/
https://www.ncbi.nlm.nih.gov/pubmed/33425913
http://dx.doi.org/10.3389/fcell.2020.606407
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