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A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction

Conjugated polyenes are a class of widely occurring natural products with various biological functions. We previously identified 4-hydroxy auxarconjugatin B (4-HAB) as anti‐inflammatory agent with an IC(50) of ~20 µM. In this study, we synthesized a new anti‐inflammatory 4-HAB analogue, F240B, which...

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Detalles Bibliográficos
Autores principales:	Wu, Chun-Hsien, Gan, Chin Heng, Li, Lan-Hui, Chang, Jen-Che, Chen, Shin-Tai, Menon, Mridula P., Cheng, Shu-Meng, Yang, Shih-Ping, Ho, Chen-Lung, Chernikov, Oleg V., Lin, Chi-Hung, Lam, Yulin, Hua, Kuo-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793731/ https://www.ncbi.nlm.nih.gov/pubmed/33424855 http://dx.doi.org/10.3389/fimmu.2020.607564

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