Cargando…

Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder

A lot of previous studies have documented that major depressive disorder (MDD) is a developmental disorder. The cortical surface measure, local gyrification index (LGI), can well reflect the fetal and early postnatal neurodevelopmental processes. Thus, LGI may provide new insight for the neuropathol...

Descripción completa

Detalles Bibliográficos
Autores principales: Long, Jiang, Xu, Jinping, Wang, Xue, Li, Jin, Rao, Shan, Wu, Huawang, Kuang, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793885/
https://www.ncbi.nlm.nih.gov/pubmed/33424661
http://dx.doi.org/10.3389/fpsyt.2020.585401
_version_ 1783634089605070848
author Long, Jiang
Xu, Jinping
Wang, Xue
Li, Jin
Rao, Shan
Wu, Huawang
Kuang, Weihong
author_facet Long, Jiang
Xu, Jinping
Wang, Xue
Li, Jin
Rao, Shan
Wu, Huawang
Kuang, Weihong
author_sort Long, Jiang
collection PubMed
description A lot of previous studies have documented that major depressive disorder (MDD) is a developmental disorder. The cortical surface measure, local gyrification index (LGI), can well reflect the fetal and early postnatal neurodevelopmental processes. Thus, LGI may provide new insight for the neuropathology of MDD. The previous studies only focused on the surface structural abnormality, but how the structural abnormality lead to functional connectivity changes is unexplored. In this study, we investigated LGI and corresponding functional connectivity difference in 28 medication-free MDD patients. We found significantly decreased LGI in left lingual gyrus (LING) and right posterior superior temporal sulcus (bSTS), and the changed LGI in bSTS was negatively correlated with disease onset age and anxiety scores. The following functional connectivity analyses identified decreased functional connectivities between LING and right LING, precentral gyrus, and middle temporal gyrus. The decreased functional connectivities were correlated with disease duration, onset, and depression symptoms. Our findings revealed abnormal LGI in LING and bSTS indicating that the abnormal developmental of visual and social cognition related brain areas may be an early biomarker for depression.
format Online
Article
Text
id pubmed-7793885
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77938852021-01-09 Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder Long, Jiang Xu, Jinping Wang, Xue Li, Jin Rao, Shan Wu, Huawang Kuang, Weihong Front Psychiatry Psychiatry A lot of previous studies have documented that major depressive disorder (MDD) is a developmental disorder. The cortical surface measure, local gyrification index (LGI), can well reflect the fetal and early postnatal neurodevelopmental processes. Thus, LGI may provide new insight for the neuropathology of MDD. The previous studies only focused on the surface structural abnormality, but how the structural abnormality lead to functional connectivity changes is unexplored. In this study, we investigated LGI and corresponding functional connectivity difference in 28 medication-free MDD patients. We found significantly decreased LGI in left lingual gyrus (LING) and right posterior superior temporal sulcus (bSTS), and the changed LGI in bSTS was negatively correlated with disease onset age and anxiety scores. The following functional connectivity analyses identified decreased functional connectivities between LING and right LING, precentral gyrus, and middle temporal gyrus. The decreased functional connectivities were correlated with disease duration, onset, and depression symptoms. Our findings revealed abnormal LGI in LING and bSTS indicating that the abnormal developmental of visual and social cognition related brain areas may be an early biomarker for depression. Frontiers Media S.A. 2020-12-14 /pmc/articles/PMC7793885/ /pubmed/33424661 http://dx.doi.org/10.3389/fpsyt.2020.585401 Text en Copyright © 2020 Long, Xu, Wang, Li, Rao, Wu and Kuang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Long, Jiang
Xu, Jinping
Wang, Xue
Li, Jin
Rao, Shan
Wu, Huawang
Kuang, Weihong
Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder
title Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder
title_full Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder
title_fullStr Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder
title_full_unstemmed Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder
title_short Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder
title_sort altered local gyrification index and corresponding functional connectivity in medication free major depressive disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793885/
https://www.ncbi.nlm.nih.gov/pubmed/33424661
http://dx.doi.org/10.3389/fpsyt.2020.585401
work_keys_str_mv AT longjiang alteredlocalgyrificationindexandcorrespondingfunctionalconnectivityinmedicationfreemajordepressivedisorder
AT xujinping alteredlocalgyrificationindexandcorrespondingfunctionalconnectivityinmedicationfreemajordepressivedisorder
AT wangxue alteredlocalgyrificationindexandcorrespondingfunctionalconnectivityinmedicationfreemajordepressivedisorder
AT lijin alteredlocalgyrificationindexandcorrespondingfunctionalconnectivityinmedicationfreemajordepressivedisorder
AT raoshan alteredlocalgyrificationindexandcorrespondingfunctionalconnectivityinmedicationfreemajordepressivedisorder
AT wuhuawang alteredlocalgyrificationindexandcorrespondingfunctionalconnectivityinmedicationfreemajordepressivedisorder
AT kuangweihong alteredlocalgyrificationindexandcorrespondingfunctionalconnectivityinmedicationfreemajordepressivedisorder