Cargando…

The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?

Endocytic recycling is an intracellular process that returns internalized molecules back to the plasma membrane and plays crucial roles not only in the reuse of receptor molecules but also in the remodeling of the different components of this membrane. This process is required for a diversity of cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Rozés-Salvador, Victoria, González-Billault, Christian, Conde, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793921/
https://www.ncbi.nlm.nih.gov/pubmed/33425908
http://dx.doi.org/10.3389/fcell.2020.603794
_version_ 1783634098256871424
author Rozés-Salvador, Victoria
González-Billault, Christian
Conde, Cecilia
author_facet Rozés-Salvador, Victoria
González-Billault, Christian
Conde, Cecilia
author_sort Rozés-Salvador, Victoria
collection PubMed
description Endocytic recycling is an intracellular process that returns internalized molecules back to the plasma membrane and plays crucial roles not only in the reuse of receptor molecules but also in the remodeling of the different components of this membrane. This process is required for a diversity of cellular events, including neuronal morphology acquisition and functional regulation, among others. The recycling endosome (RE) is a key vesicular component involved in endocytic recycling. Recycling back to the cell surface may occur with the participation of several different Rab proteins, which are master regulators of membrane/protein trafficking in nerve cells. The RE consists of a network of interconnected and functionally distinct tubular subdomains that originate from sorting endosomes and transport their cargoes along microtubule tracks, by fast or slow recycling pathways. Different populations of REs, particularly those formed by Rab11, Rab35, and Arf6, are associated with a myriad of signaling proteins. In this review, we discuss the cumulative evidence suggesting the existence of heterogeneous domains of REs, controlling different aspects of neurogenesis, with a particular focus on the commonalities and singularities of these REs and their contribution to nerve development and differentiation in several animal models.
format Online
Article
Text
id pubmed-7793921
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77939212021-01-09 The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All? Rozés-Salvador, Victoria González-Billault, Christian Conde, Cecilia Front Cell Dev Biol Cell and Developmental Biology Endocytic recycling is an intracellular process that returns internalized molecules back to the plasma membrane and plays crucial roles not only in the reuse of receptor molecules but also in the remodeling of the different components of this membrane. This process is required for a diversity of cellular events, including neuronal morphology acquisition and functional regulation, among others. The recycling endosome (RE) is a key vesicular component involved in endocytic recycling. Recycling back to the cell surface may occur with the participation of several different Rab proteins, which are master regulators of membrane/protein trafficking in nerve cells. The RE consists of a network of interconnected and functionally distinct tubular subdomains that originate from sorting endosomes and transport their cargoes along microtubule tracks, by fast or slow recycling pathways. Different populations of REs, particularly those formed by Rab11, Rab35, and Arf6, are associated with a myriad of signaling proteins. In this review, we discuss the cumulative evidence suggesting the existence of heterogeneous domains of REs, controlling different aspects of neurogenesis, with a particular focus on the commonalities and singularities of these REs and their contribution to nerve development and differentiation in several animal models. Frontiers Media S.A. 2020-12-10 /pmc/articles/PMC7793921/ /pubmed/33425908 http://dx.doi.org/10.3389/fcell.2020.603794 Text en Copyright © 2020 Rozés-Salvador, González-Billault and Conde. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Rozés-Salvador, Victoria
González-Billault, Christian
Conde, Cecilia
The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?
title The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?
title_full The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?
title_fullStr The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?
title_full_unstemmed The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?
title_short The Recycling Endosome in Nerve Cell Development: One Rab to Rule Them All?
title_sort recycling endosome in nerve cell development: one rab to rule them all?
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793921/
https://www.ncbi.nlm.nih.gov/pubmed/33425908
http://dx.doi.org/10.3389/fcell.2020.603794
work_keys_str_mv AT rozessalvadorvictoria therecyclingendosomeinnervecelldevelopmentonerabtorulethemall
AT gonzalezbillaultchristian therecyclingendosomeinnervecelldevelopmentonerabtorulethemall
AT condececilia therecyclingendosomeinnervecelldevelopmentonerabtorulethemall
AT rozessalvadorvictoria recyclingendosomeinnervecelldevelopmentonerabtorulethemall
AT gonzalezbillaultchristian recyclingendosomeinnervecelldevelopmentonerabtorulethemall
AT condececilia recyclingendosomeinnervecelldevelopmentonerabtorulethemall