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Interplay Between KSHV and the Host DNA Damage Response
Interactions between viruses and cellular factors are essential for viral replication or host defense. The DNA damage response (DDR) orchestrates a molecular network of cellular mechanisms that integrates cell cycle regulation and DNA repair or apoptosis. Numerous studies have revealed that the DDR...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793933/ https://www.ncbi.nlm.nih.gov/pubmed/33425783 http://dx.doi.org/10.3389/fcimb.2020.604351 |
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author | Ohsaki, Eriko Ueda, Keiji |
author_facet | Ohsaki, Eriko Ueda, Keiji |
author_sort | Ohsaki, Eriko |
collection | PubMed |
description | Interactions between viruses and cellular factors are essential for viral replication or host defense. The DNA damage response (DDR) orchestrates a molecular network of cellular mechanisms that integrates cell cycle regulation and DNA repair or apoptosis. Numerous studies have revealed that the DDR is activated by virus infection, aberrant DNA structures generated by viral DNA replication, or the integration of retroviruses. Although the DDR is an essential function for maintaining the genomic integrity of cells, viruses may utilize this mechanism to build a convenient environment for themselves, and the resulting perturbation of the DDR has been shown to increase the risk of tumorigenesis. There have been many studies investigating the roles of the DDR in oncogenic viruses such as Epstein-Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), human T-cell leukemia virus type 1 (HTLV-1), and Kaposi’s sarcoma-associated herpesvirus (KSHV). This review summarizes current knowledge on the roles of DDR in the KSHV lifecycle. |
format | Online Article Text |
id | pubmed-7793933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77939332021-01-09 Interplay Between KSHV and the Host DNA Damage Response Ohsaki, Eriko Ueda, Keiji Front Cell Infect Microbiol Cellular and Infection Microbiology Interactions between viruses and cellular factors are essential for viral replication or host defense. The DNA damage response (DDR) orchestrates a molecular network of cellular mechanisms that integrates cell cycle regulation and DNA repair or apoptosis. Numerous studies have revealed that the DDR is activated by virus infection, aberrant DNA structures generated by viral DNA replication, or the integration of retroviruses. Although the DDR is an essential function for maintaining the genomic integrity of cells, viruses may utilize this mechanism to build a convenient environment for themselves, and the resulting perturbation of the DDR has been shown to increase the risk of tumorigenesis. There have been many studies investigating the roles of the DDR in oncogenic viruses such as Epstein-Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), human T-cell leukemia virus type 1 (HTLV-1), and Kaposi’s sarcoma-associated herpesvirus (KSHV). This review summarizes current knowledge on the roles of DDR in the KSHV lifecycle. Frontiers Media S.A. 2020-12-09 /pmc/articles/PMC7793933/ /pubmed/33425783 http://dx.doi.org/10.3389/fcimb.2020.604351 Text en Copyright © 2020 Ohsaki and Ueda http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Ohsaki, Eriko Ueda, Keiji Interplay Between KSHV and the Host DNA Damage Response |
title | Interplay Between KSHV and the Host DNA Damage Response |
title_full | Interplay Between KSHV and the Host DNA Damage Response |
title_fullStr | Interplay Between KSHV and the Host DNA Damage Response |
title_full_unstemmed | Interplay Between KSHV and the Host DNA Damage Response |
title_short | Interplay Between KSHV and the Host DNA Damage Response |
title_sort | interplay between kshv and the host dna damage response |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793933/ https://www.ncbi.nlm.nih.gov/pubmed/33425783 http://dx.doi.org/10.3389/fcimb.2020.604351 |
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