Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance

RATIONALE: Metabotropic glutamate type 5 receptor (mGluR5) antagonists are under development for treating cognitive disorders such as Fragile X syndrome and Alzheimer’s disease, largely based on success in mouse models, where post-synaptic mGluR5 stimulation weakens synaptic functions in hippocampus...

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Detalles Bibliográficos
Autores principales: Yang, Sheng-Tao, Wang, Min, Galvin, Veronica, Yang, Yang, Arnsten, Amy F. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794104/
https://www.ncbi.nlm.nih.gov/pubmed/32939596
http://dx.doi.org/10.1007/s00213-020-05661-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794104/
https://www.ncbi.nlm.nih.gov/pubmed/32939596
http://dx.doi.org/10.1007/s00213-020-05661-2

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