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Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance
RATIONALE: Metabotropic glutamate type 5 receptor (mGluR5) antagonists are under development for treating cognitive disorders such as Fragile X syndrome and Alzheimer’s disease, largely based on success in mouse models, where post-synaptic mGluR5 stimulation weakens synaptic functions in hippocampus...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794104/ https://www.ncbi.nlm.nih.gov/pubmed/32939596 http://dx.doi.org/10.1007/s00213-020-05661-2 |