Cargando…
Efficacy of Platelet Rich Fibrin in Myringoplasty
OBJECTIVE: To determine the efficacy of usage of topical autologous platelet rich fibrin (PRF) in improving outcomes of myringoplasty regarding graft uptake and hearing improvement. METHODS: This study was conducted in the ENT department of Holy Family Hospital, Rawalpindi, over a period of six mont...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794144/ https://www.ncbi.nlm.nih.gov/pubmed/33437279 http://dx.doi.org/10.12669/pjms.37.1.3059 |
_version_ | 1783634147408871424 |
---|---|
author | Riaz, Nida Ajmal, Muhammad Khan, Muhammad Sheharyar |
author_facet | Riaz, Nida Ajmal, Muhammad Khan, Muhammad Sheharyar |
author_sort | Riaz, Nida |
collection | PubMed |
description | OBJECTIVE: To determine the efficacy of usage of topical autologous platelet rich fibrin (PRF) in improving outcomes of myringoplasty regarding graft uptake and hearing improvement. METHODS: This study was conducted in the ENT department of Holy Family Hospital, Rawalpindi, over a period of six months from August 2019 to January 2020. It was designed as a prospective single blinded randomized controlled trial. The study involved a total of 50 participants in whom myringoplasty was done through post auricular approach using underlay technique. In 25 patients topical drops of PRF were used. Outcomes were compared after three months with the control group (n=25), who underwent myringoplasty without PRF. RESULTS: After three months follow-up, graft uptake was reported 78% and 52% in cases and controls, respectively (P=0.070). Mean hearing improvement was 18 dB and 6 dB in cases and controls, respectively (P=0.014). Postoperative infection occurred in 8% of the cases, and in 32% controls (P=0.037). CONCLUSION: Topical use of Platelet-Rich Fibrin during myringoplasty results in improved graft uptake. Hence, resulting in much improved hearing, significant reduction in infection rates and decrease in perforation sizes. |
format | Online Article Text |
id | pubmed-7794144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77941442021-01-11 Efficacy of Platelet Rich Fibrin in Myringoplasty Riaz, Nida Ajmal, Muhammad Khan, Muhammad Sheharyar Pak J Med Sci Original Article OBJECTIVE: To determine the efficacy of usage of topical autologous platelet rich fibrin (PRF) in improving outcomes of myringoplasty regarding graft uptake and hearing improvement. METHODS: This study was conducted in the ENT department of Holy Family Hospital, Rawalpindi, over a period of six months from August 2019 to January 2020. It was designed as a prospective single blinded randomized controlled trial. The study involved a total of 50 participants in whom myringoplasty was done through post auricular approach using underlay technique. In 25 patients topical drops of PRF were used. Outcomes were compared after three months with the control group (n=25), who underwent myringoplasty without PRF. RESULTS: After three months follow-up, graft uptake was reported 78% and 52% in cases and controls, respectively (P=0.070). Mean hearing improvement was 18 dB and 6 dB in cases and controls, respectively (P=0.014). Postoperative infection occurred in 8% of the cases, and in 32% controls (P=0.037). CONCLUSION: Topical use of Platelet-Rich Fibrin during myringoplasty results in improved graft uptake. Hence, resulting in much improved hearing, significant reduction in infection rates and decrease in perforation sizes. Professional Medical Publications 2021 /pmc/articles/PMC7794144/ /pubmed/33437279 http://dx.doi.org/10.12669/pjms.37.1.3059 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Riaz, Nida Ajmal, Muhammad Khan, Muhammad Sheharyar Efficacy of Platelet Rich Fibrin in Myringoplasty |
title | Efficacy of Platelet Rich Fibrin in Myringoplasty |
title_full | Efficacy of Platelet Rich Fibrin in Myringoplasty |
title_fullStr | Efficacy of Platelet Rich Fibrin in Myringoplasty |
title_full_unstemmed | Efficacy of Platelet Rich Fibrin in Myringoplasty |
title_short | Efficacy of Platelet Rich Fibrin in Myringoplasty |
title_sort | efficacy of platelet rich fibrin in myringoplasty |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794144/ https://www.ncbi.nlm.nih.gov/pubmed/33437279 http://dx.doi.org/10.12669/pjms.37.1.3059 |
work_keys_str_mv | AT riaznida efficacyofplateletrichfibrininmyringoplasty AT ajmalmuhammad efficacyofplateletrichfibrininmyringoplasty AT khanmuhammadsheharyar efficacyofplateletrichfibrininmyringoplasty |