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Cyclin Pathway Genomic Alterations Across 190,247 Solid Tumors: Leveraging Large‐Scale Data to Inform Therapeutic Directions

BACKGROUND: We describe the landscape of cyclin and interactive gene pathway alterations in 190,247 solid tumors. METHODS: Using comprehensive genomic profiling (315 genes, >500× coverage), samples were analyzed for alterations in activating/sensitizing cyclin genes (CDK4 amplification, CDK6 ampl...

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Detalles Bibliográficos
Autores principales:	Jardim, Denis L., Millis, Sherri Z., Ross, Jeffrey S., Woo, Michelle Sue‐Ann, Ali, Siraj M., Kurzrock, Razelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Cancer Diagnostics and Molecular Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794175/ https://www.ncbi.nlm.nih.gov/pubmed/32885893 http://dx.doi.org/10.1634/theoncologist.2020-0509

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