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Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria

Host–pathogen interaction is one of the most powerful determinants involved in coevolutionary processes covering a broad range of biological phenomena at molecular, cellular, organismal and/or population level. The present study explored host–pathogen interaction from the perspective of human–bacter...

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Autores principales: Acharya, Debarun, Dutta, Tapan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794237/
https://www.ncbi.nlm.nih.gov/pubmed/33420198
http://dx.doi.org/10.1038/s41598-020-80549-x
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author Acharya, Debarun
Dutta, Tapan K.
author_facet Acharya, Debarun
Dutta, Tapan K.
author_sort Acharya, Debarun
collection PubMed
description Host–pathogen interaction is one of the most powerful determinants involved in coevolutionary processes covering a broad range of biological phenomena at molecular, cellular, organismal and/or population level. The present study explored host–pathogen interaction from the perspective of human–bacteria protein–protein interaction based on large-scale interspecific and intraspecific interactome data for human and three pathogenic bacterial species, Bacillus anthracis, Francisella tularensis and Yersinia pestis. The network features revealed a preferential enrichment of intraspecific hubs and bottlenecks for both human and bacterial pathogens in the interspecific human–bacteria interaction. Analyses unveiled that these bacterial pathogens interact mostly with human party-hubs that may enable them to affect desired functional modules, leading to pathogenesis. Structural features of pathogen-interacting human proteins indicated an abundance of protein domains, providing opportunities for interspecific domain-domain interactions. Moreover, these interactions do not always occur with high-affinity, as we observed that bacteria-interacting human proteins are rich in protein-disorder content, which correlates positively with the number of interacting pathogen proteins, facilitating low-affinity interspecific interactions. Furthermore, functional analyses of pathogen-interacting human proteins revealed an enrichment in regulation of processes like metabolism, immune system, cellular localization and transport apart from divulging functional competence to bind enzyme/protein, nucleic acids and cell adhesion molecules, necessary for host-microbial cross-talk.
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spelling pubmed-77942372021-01-11 Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria Acharya, Debarun Dutta, Tapan K. Sci Rep Article Host–pathogen interaction is one of the most powerful determinants involved in coevolutionary processes covering a broad range of biological phenomena at molecular, cellular, organismal and/or population level. The present study explored host–pathogen interaction from the perspective of human–bacteria protein–protein interaction based on large-scale interspecific and intraspecific interactome data for human and three pathogenic bacterial species, Bacillus anthracis, Francisella tularensis and Yersinia pestis. The network features revealed a preferential enrichment of intraspecific hubs and bottlenecks for both human and bacterial pathogens in the interspecific human–bacteria interaction. Analyses unveiled that these bacterial pathogens interact mostly with human party-hubs that may enable them to affect desired functional modules, leading to pathogenesis. Structural features of pathogen-interacting human proteins indicated an abundance of protein domains, providing opportunities for interspecific domain-domain interactions. Moreover, these interactions do not always occur with high-affinity, as we observed that bacteria-interacting human proteins are rich in protein-disorder content, which correlates positively with the number of interacting pathogen proteins, facilitating low-affinity interspecific interactions. Furthermore, functional analyses of pathogen-interacting human proteins revealed an enrichment in regulation of processes like metabolism, immune system, cellular localization and transport apart from divulging functional competence to bind enzyme/protein, nucleic acids and cell adhesion molecules, necessary for host-microbial cross-talk. Nature Publishing Group UK 2021-01-08 /pmc/articles/PMC7794237/ /pubmed/33420198 http://dx.doi.org/10.1038/s41598-020-80549-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Acharya, Debarun
Dutta, Tapan K.
Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria
title Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria
title_full Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria
title_fullStr Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria
title_full_unstemmed Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria
title_short Elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria
title_sort elucidating the network features and evolutionary attributes of intra- and interspecific protein–protein interactions between human and pathogenic bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794237/
https://www.ncbi.nlm.nih.gov/pubmed/33420198
http://dx.doi.org/10.1038/s41598-020-80549-x
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