Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype

Interleukin (IL)-33 is a cytokine that appears to mediate fibrosis by signaling via its receptor ST2 (IL-33R/IL1RL1). It is also, however, a protein that after synthesis is sorted to the cell nucleus, where it appears to affect chromatin folding. Here we describe a novel role for nuclear IL-33 in re...

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Detalles Bibliográficos
Autores principales: Gatti, Francesca, Mia, Sobuj, Hammarström, Clara, Frerker, Nadine, Fosby, Bjarte, Wang, Junbai, Pietka, Wojciech, Sundnes, Olav, Hol, Johanna, Kasprzycka, Monika, Haraldsen, Guttorm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794291/
https://www.ncbi.nlm.nih.gov/pubmed/33420328
http://dx.doi.org/10.1038/s41598-020-80509-5

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