Emerging role of SWI/SNF complex deficiency as a target of immune checkpoint blockade in human cancers

Mammalian SWI/SNF complex is a key chromatin remodeler that reshapes nucleosomes and regulates DNA accessibility. Mutations in SWI/SNF subunits are found in a broad spectrum of human cancers; however, the mechanisms of how these aberrations of SWI/SNF complex would impact tumorigenesis and cancer th...

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Detalles Bibliográficos
Autores principales: Zhou, Min, Yuan, Jianlong, Deng, Yaqi, Fan, Xianqun, Shen, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794300/
https://www.ncbi.nlm.nih.gov/pubmed/33419967
http://dx.doi.org/10.1038/s41389-020-00296-6

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