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Smoking status and endothelial function in Japanese men
It is established that smoking is a major risk factor of atherosclerosis. Endothelial dysfunction occurs in the initial step in the pathogenesis of atherosclerosis and plays a critical role in the development of atherosclerosis. The purpose of this study was to evaluate the association between smoki...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794366/ https://www.ncbi.nlm.nih.gov/pubmed/33420173 http://dx.doi.org/10.1038/s41598-020-80012-x |
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author | Hashimoto, Haruki Maruhashi, Tatsuya Yamaji, Takayuki Harada, Takahiro Han, Yiming Takaeko, Yuji Kihara, Yasuki Chayama, Kazuaki Goto, Chikara Aibara, Yoshiki Yusoff, Farina Mohamad Kishimoto, Shinji Kajikawa, Masato Nakashima, Ayumu Higashi, Yukihito |
author_facet | Hashimoto, Haruki Maruhashi, Tatsuya Yamaji, Takayuki Harada, Takahiro Han, Yiming Takaeko, Yuji Kihara, Yasuki Chayama, Kazuaki Goto, Chikara Aibara, Yoshiki Yusoff, Farina Mohamad Kishimoto, Shinji Kajikawa, Masato Nakashima, Ayumu Higashi, Yukihito |
author_sort | Hashimoto, Haruki |
collection | PubMed |
description | It is established that smoking is a major risk factor of atherosclerosis. Endothelial dysfunction occurs in the initial step in the pathogenesis of atherosclerosis and plays a critical role in the development of atherosclerosis. The purpose of this study was to evaluate the association between smoking status and endothelial function in detail in men. We measured flow-mediated vasodilation (FMD) in 2209 Japanese men including 1181 men who had never smoked and 1028 current smokers. All of the participants were divided into five groups by smoking pack-years: never smoker group (= 0), light smoker group (> 0 to 10), moderate smoker group (> 10 to 20), heavy smoker group (> 20 to 30) and excessive smoker group (> 30). FMD significantly decreased in relation to pack-years (6.6 ± 3.4% in the never smoker group, 6.8 ± 3.0% in the light smoker group, 6.5 ± 2.9% in the moderate smoker group, 5.9 ± 2.9% in the heavy smoker group, and 4.9 ± 2.7% in the excessive smoker group; P < 0.001). After adjustment for age (≥ 65 years), body mass index, systolic blood pressure, low-density lipoprotein cholesterol, glucose, and year of recruitment, FMD was significantly smaller in the excessive smoker group than in the never smoker group as a reference group (OR 1.95, 95% CI 1.42 to 2.67; P < 0.001). These findings suggest that FMD decreases with an increase in the number of cigarettes smoked and that excessive smoking is associated with endothelial dysfunction. Cigarette smoking is harmful to vascular function in men who are heavy smokers. |
format | Online Article Text |
id | pubmed-7794366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77943662021-01-11 Smoking status and endothelial function in Japanese men Hashimoto, Haruki Maruhashi, Tatsuya Yamaji, Takayuki Harada, Takahiro Han, Yiming Takaeko, Yuji Kihara, Yasuki Chayama, Kazuaki Goto, Chikara Aibara, Yoshiki Yusoff, Farina Mohamad Kishimoto, Shinji Kajikawa, Masato Nakashima, Ayumu Higashi, Yukihito Sci Rep Article It is established that smoking is a major risk factor of atherosclerosis. Endothelial dysfunction occurs in the initial step in the pathogenesis of atherosclerosis and plays a critical role in the development of atherosclerosis. The purpose of this study was to evaluate the association between smoking status and endothelial function in detail in men. We measured flow-mediated vasodilation (FMD) in 2209 Japanese men including 1181 men who had never smoked and 1028 current smokers. All of the participants were divided into five groups by smoking pack-years: never smoker group (= 0), light smoker group (> 0 to 10), moderate smoker group (> 10 to 20), heavy smoker group (> 20 to 30) and excessive smoker group (> 30). FMD significantly decreased in relation to pack-years (6.6 ± 3.4% in the never smoker group, 6.8 ± 3.0% in the light smoker group, 6.5 ± 2.9% in the moderate smoker group, 5.9 ± 2.9% in the heavy smoker group, and 4.9 ± 2.7% in the excessive smoker group; P < 0.001). After adjustment for age (≥ 65 years), body mass index, systolic blood pressure, low-density lipoprotein cholesterol, glucose, and year of recruitment, FMD was significantly smaller in the excessive smoker group than in the never smoker group as a reference group (OR 1.95, 95% CI 1.42 to 2.67; P < 0.001). These findings suggest that FMD decreases with an increase in the number of cigarettes smoked and that excessive smoking is associated with endothelial dysfunction. Cigarette smoking is harmful to vascular function in men who are heavy smokers. Nature Publishing Group UK 2021-01-08 /pmc/articles/PMC7794366/ /pubmed/33420173 http://dx.doi.org/10.1038/s41598-020-80012-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hashimoto, Haruki Maruhashi, Tatsuya Yamaji, Takayuki Harada, Takahiro Han, Yiming Takaeko, Yuji Kihara, Yasuki Chayama, Kazuaki Goto, Chikara Aibara, Yoshiki Yusoff, Farina Mohamad Kishimoto, Shinji Kajikawa, Masato Nakashima, Ayumu Higashi, Yukihito Smoking status and endothelial function in Japanese men |
title | Smoking status and endothelial function in Japanese men |
title_full | Smoking status and endothelial function in Japanese men |
title_fullStr | Smoking status and endothelial function in Japanese men |
title_full_unstemmed | Smoking status and endothelial function in Japanese men |
title_short | Smoking status and endothelial function in Japanese men |
title_sort | smoking status and endothelial function in japanese men |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794366/ https://www.ncbi.nlm.nih.gov/pubmed/33420173 http://dx.doi.org/10.1038/s41598-020-80012-x |
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