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Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study

In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a multicentre study from 6 andrological centres were ret...

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Autores principales: Cocci, Andrea, Ralph, David, Djinovic, Rados, Hatzichristodoulou, Georgios, Morelli, Girolamo, Salonia, Andrea, Capogrosso, Paolo, Romano, Andrea, Cito, Gianmartin, Di Maida, Fabrizio, Fernández-Pascual, Esaú, Romero-Otero, Javier, Egydio, Paulo, Falcone, Marco, Preto, Mirko, Chiriacò, Giovanni, Beck, Jack, Albersen, Maarten, Minhas, Suks, Cacciamani, Giovanni, Salamanca, Juan Ignacio Martinez, Mondani, Nicola, Minervini, Andrea, Russo, Giorgio Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794401/
https://www.ncbi.nlm.nih.gov/pubmed/33420247
http://dx.doi.org/10.1038/s41598-020-80551-3
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author Cocci, Andrea
Ralph, David
Djinovic, Rados
Hatzichristodoulou, Georgios
Morelli, Girolamo
Salonia, Andrea
Capogrosso, Paolo
Romano, Andrea
Cito, Gianmartin
Di Maida, Fabrizio
Fernández-Pascual, Esaú
Romero-Otero, Javier
Egydio, Paulo
Falcone, Marco
Preto, Mirko
Chiriacò, Giovanni
Beck, Jack
Albersen, Maarten
Minhas, Suks
Cacciamani, Giovanni
Salamanca, Juan Ignacio Martinez
Mondani, Nicola
Minervini, Andrea
Russo, Giorgio Ivan
author_facet Cocci, Andrea
Ralph, David
Djinovic, Rados
Hatzichristodoulou, Georgios
Morelli, Girolamo
Salonia, Andrea
Capogrosso, Paolo
Romano, Andrea
Cito, Gianmartin
Di Maida, Fabrizio
Fernández-Pascual, Esaú
Romero-Otero, Javier
Egydio, Paulo
Falcone, Marco
Preto, Mirko
Chiriacò, Giovanni
Beck, Jack
Albersen, Maarten
Minhas, Suks
Cacciamani, Giovanni
Salamanca, Juan Ignacio Martinez
Mondani, Nicola
Minervini, Andrea
Russo, Giorgio Ivan
author_sort Cocci, Andrea
collection PubMed
description In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a multicentre study from 6 andrological centres were retrospectively reviewed. Three standardized surgical techniques were performed. Group 1: plaque incision grafting (PIG) with penile prosthesis implant (PPI); Group 2: PIG without PPI; Group 3: Nesbit technique. Hospital stay, operative time, postoperative complications and PC persistency/recurrence (> 20°) were evaluated. Overall satisfaction and functional outcomes were assessed through International Index of Erectile Function-Erectile Function (IIEF-EF), Peyronie’s Disease Questionnaire (PDQ), Female Sexual Function Index (FSFI) administered pre and 3 months postoperatively. Of all, 25 (27.8%) patients received grafting procedure + PPI (Group 1), 18 (20.0%) patients belonged to Group 2, and 47 (52.2%) to Group 3. Bovine pericardium graft and collagen fleece have been used in in 22 (51.2%) and 21 (48.8%) patients, respectively. Median penile length after surgery was 13.0 cm (IQR 12.0–15.0). After surgery, Group 1 showed higher increase in penile length after surgery and better improvements in terms of PDQ-PS. In contrast, both IIEF-EF and FSFI scores did not differ among groups. Overall, 86 (95.6%) did not report any complication. 4 (4.4%) patients had PC recurrence; of those, 2 (8.0%), 1 (5.6%) and 1 (2.1%) cases were observed in Group 1, Group 2 and Group 3, respectively. In case of persistent PC after CCH, surgical correction by grafting with or without concomitant PPI or Nesbit technique emerged as a technically feasible, effective and safe procedure, with no significant postoperative complications.
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spelling pubmed-77944012021-01-11 Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study Cocci, Andrea Ralph, David Djinovic, Rados Hatzichristodoulou, Georgios Morelli, Girolamo Salonia, Andrea Capogrosso, Paolo Romano, Andrea Cito, Gianmartin Di Maida, Fabrizio Fernández-Pascual, Esaú Romero-Otero, Javier Egydio, Paulo Falcone, Marco Preto, Mirko Chiriacò, Giovanni Beck, Jack Albersen, Maarten Minhas, Suks Cacciamani, Giovanni Salamanca, Juan Ignacio Martinez Mondani, Nicola Minervini, Andrea Russo, Giorgio Ivan Sci Rep Article In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a multicentre study from 6 andrological centres were retrospectively reviewed. Three standardized surgical techniques were performed. Group 1: plaque incision grafting (PIG) with penile prosthesis implant (PPI); Group 2: PIG without PPI; Group 3: Nesbit technique. Hospital stay, operative time, postoperative complications and PC persistency/recurrence (> 20°) were evaluated. Overall satisfaction and functional outcomes were assessed through International Index of Erectile Function-Erectile Function (IIEF-EF), Peyronie’s Disease Questionnaire (PDQ), Female Sexual Function Index (FSFI) administered pre and 3 months postoperatively. Of all, 25 (27.8%) patients received grafting procedure + PPI (Group 1), 18 (20.0%) patients belonged to Group 2, and 47 (52.2%) to Group 3. Bovine pericardium graft and collagen fleece have been used in in 22 (51.2%) and 21 (48.8%) patients, respectively. Median penile length after surgery was 13.0 cm (IQR 12.0–15.0). After surgery, Group 1 showed higher increase in penile length after surgery and better improvements in terms of PDQ-PS. In contrast, both IIEF-EF and FSFI scores did not differ among groups. Overall, 86 (95.6%) did not report any complication. 4 (4.4%) patients had PC recurrence; of those, 2 (8.0%), 1 (5.6%) and 1 (2.1%) cases were observed in Group 1, Group 2 and Group 3, respectively. In case of persistent PC after CCH, surgical correction by grafting with or without concomitant PPI or Nesbit technique emerged as a technically feasible, effective and safe procedure, with no significant postoperative complications. Nature Publishing Group UK 2021-01-08 /pmc/articles/PMC7794401/ /pubmed/33420247 http://dx.doi.org/10.1038/s41598-020-80551-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cocci, Andrea
Ralph, David
Djinovic, Rados
Hatzichristodoulou, Georgios
Morelli, Girolamo
Salonia, Andrea
Capogrosso, Paolo
Romano, Andrea
Cito, Gianmartin
Di Maida, Fabrizio
Fernández-Pascual, Esaú
Romero-Otero, Javier
Egydio, Paulo
Falcone, Marco
Preto, Mirko
Chiriacò, Giovanni
Beck, Jack
Albersen, Maarten
Minhas, Suks
Cacciamani, Giovanni
Salamanca, Juan Ignacio Martinez
Mondani, Nicola
Minervini, Andrea
Russo, Giorgio Ivan
Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_full Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_fullStr Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_full_unstemmed Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_short Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_sort surgical outcomes after collagenase clostridium histolyticum failure in patients with peyronie’s disease in a multicenter clinical study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794401/
https://www.ncbi.nlm.nih.gov/pubmed/33420247
http://dx.doi.org/10.1038/s41598-020-80551-3
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