Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers

The dimeric transporter, EmrE, effluxes polyaromatic cationic drugs in a proton-coupled manner to confer multidrug resistance in bacteria. Although the protein is known to adopt an antiparallel asymmetric topology, its high-resolution drug-bound structure is so far unknown, limiting our understandin...

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Detalles Bibliográficos
Autores principales: Shcherbakov, Alexander A., Hisao, Grant, Mandala, Venkata S., Thomas, Nathan E., Soltani, Mohammad, Salter, E. A., Davis, James H., Henzler-Wildman, Katherine A., Hong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794478/
https://www.ncbi.nlm.nih.gov/pubmed/33420032
http://dx.doi.org/10.1038/s41467-020-20468-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794478/
https://www.ncbi.nlm.nih.gov/pubmed/33420032
http://dx.doi.org/10.1038/s41467-020-20468-7

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