Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I triggers the AMP-activated protein kinase-dependent signaling networ...

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Detalles Bibliográficos
Autores principales: Stojakovic, Andrea, Trushin, Sergey, Sheu, Anthony, Khalili, Layla, Chang, Su-Youne, Li, Xing, Christensen, Trace, Salisbury, Jeffrey L., Geroux, Rachel E., Gateno, Benjamin, Flannery, Padraig J., Dehankar, Mrunal, Funk, Cory C., Wilkins, Jordan, Stepanova, Anna, O’Hagan, Tara, Galkin, Alexander, Nesbitt, Jarred, Zhu, Xiujuan, Tripathi, Utkarsh, Macura, Slobodan, Tchkonia, Tamar, Pirtskhalava, Tamar, Kirkland, James L., Kudgus, Rachel A., Schoon, Renee A., Reid, Joel M., Yamazaki, Yu, Kanekiyo, Takahisa, Zhang, Song, Nemutlu, Emirhan, Dzeja, Petras, Jaspersen, Adam, Kwon, Ye In Christopher, Lee, Michael K., Trushina, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794523/
https://www.ncbi.nlm.nih.gov/pubmed/33420340
http://dx.doi.org/10.1038/s42003-020-01584-y

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