A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability

TRPV1, a member of the transient receptor potential (TRP) family, is a nonselective calcium permeable ion channel gated by physical and chemical stimuli. In the skin, TRPV1 plays an important role in neurogenic inflammation, pain and pruritus associated to many dermatological diseases. Consequently,...

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Detalles Bibliográficos
Autores principales: Nikolaeva-Koleva, Magdalena, Butron, Laura, González-Rodríguez, Sara, Devesa, Isabel, Valente, Pierluigi, Serafini, Marta, Genazzani, Armando A., Pirali, Tracey, Ballester, Gregorio Fernández, Fernández-Carvajal, Asia, Ferrer-Montiel, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794549/
https://www.ncbi.nlm.nih.gov/pubmed/33420359
http://dx.doi.org/10.1038/s41598-020-80725-z

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