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Multi-organ proteomic landscape of COVID-19 autopsies
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 w...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794601/ https://www.ncbi.nlm.nih.gov/pubmed/33503446 http://dx.doi.org/10.1016/j.cell.2021.01.004 |
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| author | Nie, Xiu Qian, Liujia Sun, Rui Huang, Bo Dong, Xiaochuan Xiao, Qi Zhang, Qiushi Lu, Tian Yue, Liang Chen, Shuo Li, Xiang Sun, Yaoting Li, Lu Xu, Luang Li, Yan Yang, Ming Xue, Zhangzhi Liang, Shuang Ding, Xuan Yuan, Chunhui Peng, Li Liu, Wei Yi, Xiao Lyu, Mengge Xiao, Guixiang Xu, Xia Ge, Weigang He, Jiale Fan, Jun Wu, Junhua Luo, Meng Chang, Xiaona Pan, Huaxiong Cai, Xue Zhou, Junjie Yu, Jing Gao, Huanhuan Xie, Mingxing Wang, Sihua Ruan, Guan Chen, Hao Su, Hua Mei, Heng Luo, Danju Zhao, Dashi Xu, Fei Li, Yan Zhu, Yi Xia, Jiahong Hu, Yu Guo, Tiannan |
| author_facet | Nie, Xiu Qian, Liujia Sun, Rui Huang, Bo Dong, Xiaochuan Xiao, Qi Zhang, Qiushi Lu, Tian Yue, Liang Chen, Shuo Li, Xiang Sun, Yaoting Li, Lu Xu, Luang Li, Yan Yang, Ming Xue, Zhangzhi Liang, Shuang Ding, Xuan Yuan, Chunhui Peng, Li Liu, Wei Yi, Xiao Lyu, Mengge Xiao, Guixiang Xu, Xia Ge, Weigang He, Jiale Fan, Jun Wu, Junhua Luo, Meng Chang, Xiaona Pan, Huaxiong Cai, Xue Zhou, Junjie Yu, Jing Gao, Huanhuan Xie, Mingxing Wang, Sihua Ruan, Guan Chen, Hao Su, Hua Mei, Heng Luo, Danju Zhao, Dashi Xu, Fei Li, Yan Zhu, Yi Xia, Jiahong Hu, Yu Guo, Tiannan |
| author_sort | Nie, Xiu |
| collection | PubMed |
| description | The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperinflammation and dysregulation of glucose and fatty acid metabolism were detected in multiple organs. We also observed dysregulation of key factors involved in hypoxia, angiogenesis, blood coagulation, and fibrosis in multiple organs from the COVID-19 patients. Evidence for testicular injuries includes reduced Leydig cells, suppressed cholesterol biosynthesis, and sperm mobility. In summary, this study depicts a multi-organ proteomic landscape of COVID-19 autopsies that furthers our understanding of the biological basis of COVID-19 pathology. |
| format | Online Article Text |
| id | pubmed-7794601 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77946012021-01-11 Multi-organ proteomic landscape of COVID-19 autopsies Nie, Xiu Qian, Liujia Sun, Rui Huang, Bo Dong, Xiaochuan Xiao, Qi Zhang, Qiushi Lu, Tian Yue, Liang Chen, Shuo Li, Xiang Sun, Yaoting Li, Lu Xu, Luang Li, Yan Yang, Ming Xue, Zhangzhi Liang, Shuang Ding, Xuan Yuan, Chunhui Peng, Li Liu, Wei Yi, Xiao Lyu, Mengge Xiao, Guixiang Xu, Xia Ge, Weigang He, Jiale Fan, Jun Wu, Junhua Luo, Meng Chang, Xiaona Pan, Huaxiong Cai, Xue Zhou, Junjie Yu, Jing Gao, Huanhuan Xie, Mingxing Wang, Sihua Ruan, Guan Chen, Hao Su, Hua Mei, Heng Luo, Danju Zhao, Dashi Xu, Fei Li, Yan Zhu, Yi Xia, Jiahong Hu, Yu Guo, Tiannan Cell Resource The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperinflammation and dysregulation of glucose and fatty acid metabolism were detected in multiple organs. We also observed dysregulation of key factors involved in hypoxia, angiogenesis, blood coagulation, and fibrosis in multiple organs from the COVID-19 patients. Evidence for testicular injuries includes reduced Leydig cells, suppressed cholesterol biosynthesis, and sperm mobility. In summary, this study depicts a multi-organ proteomic landscape of COVID-19 autopsies that furthers our understanding of the biological basis of COVID-19 pathology. Elsevier Inc. 2021-02-04 2021-01-09 /pmc/articles/PMC7794601/ /pubmed/33503446 http://dx.doi.org/10.1016/j.cell.2021.01.004 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Resource Nie, Xiu Qian, Liujia Sun, Rui Huang, Bo Dong, Xiaochuan Xiao, Qi Zhang, Qiushi Lu, Tian Yue, Liang Chen, Shuo Li, Xiang Sun, Yaoting Li, Lu Xu, Luang Li, Yan Yang, Ming Xue, Zhangzhi Liang, Shuang Ding, Xuan Yuan, Chunhui Peng, Li Liu, Wei Yi, Xiao Lyu, Mengge Xiao, Guixiang Xu, Xia Ge, Weigang He, Jiale Fan, Jun Wu, Junhua Luo, Meng Chang, Xiaona Pan, Huaxiong Cai, Xue Zhou, Junjie Yu, Jing Gao, Huanhuan Xie, Mingxing Wang, Sihua Ruan, Guan Chen, Hao Su, Hua Mei, Heng Luo, Danju Zhao, Dashi Xu, Fei Li, Yan Zhu, Yi Xia, Jiahong Hu, Yu Guo, Tiannan Multi-organ proteomic landscape of COVID-19 autopsies |
| title | Multi-organ proteomic landscape of COVID-19 autopsies |
| title_full | Multi-organ proteomic landscape of COVID-19 autopsies |
| title_fullStr | Multi-organ proteomic landscape of COVID-19 autopsies |
| title_full_unstemmed | Multi-organ proteomic landscape of COVID-19 autopsies |
| title_short | Multi-organ proteomic landscape of COVID-19 autopsies |
| title_sort | multi-organ proteomic landscape of covid-19 autopsies |
| topic | Resource |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794601/ https://www.ncbi.nlm.nih.gov/pubmed/33503446 http://dx.doi.org/10.1016/j.cell.2021.01.004 |
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