Tonabersat Inhibits Connexin43 Hemichannel Opening and Inflammasome Activation in an In Vitro Retinal Epithelial Cell Model of Diabetic Retinopathy

This study was undertaken to evaluate the connexin hemichannel blocker tonabersat for the inhibition of inflammasome activation and use as a potential treatment for diabetic retinopathy. Human retinal pigment epithelial cells (ARPE-19) were stimulated with hyperglycemia and the inflammatory cytokine...

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Detalles Bibliográficos
Autores principales: Lyon, Heather, Shome, Avik, Rupenthal, Ilva D., Green, Colin R., Mugisho, Odunayo O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794685/
https://www.ncbi.nlm.nih.gov/pubmed/33396676
http://dx.doi.org/10.3390/ijms22010298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794685/
https://www.ncbi.nlm.nih.gov/pubmed/33396676
http://dx.doi.org/10.3390/ijms22010298

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