In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm...

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Autores principales: Yoon, Seung Kyun, Yang, Jin Ho, Lim, Hyun Tae, Chang, Young-Wook, Ayyoob, Muhammad, Yang, Xin, Kim, Young Jun, Ko, Han-Seung, Jho, Jae Young, Chung, Dong June
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794712/
https://www.ncbi.nlm.nih.gov/pubmed/33374878
http://dx.doi.org/10.3390/polym13010029
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author Yoon, Seung Kyun
Yang, Jin Ho
Lim, Hyun Tae
Chang, Young-Wook
Ayyoob, Muhammad
Yang, Xin
Kim, Young Jun
Ko, Han-Seung
Jho, Jae Young
Chung, Dong June
author_facet Yoon, Seung Kyun
Yang, Jin Ho
Lim, Hyun Tae
Chang, Young-Wook
Ayyoob, Muhammad
Yang, Xin
Kim, Young Jun
Ko, Han-Seung
Jho, Jae Young
Chung, Dong June
author_sort Yoon, Seung Kyun
collection PubMed
description Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.
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spelling pubmed-77947122021-01-10 In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation Yoon, Seung Kyun Yang, Jin Ho Lim, Hyun Tae Chang, Young-Wook Ayyoob, Muhammad Yang, Xin Kim, Young Jun Ko, Han-Seung Jho, Jae Young Chung, Dong June Polymers (Basel) Article Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials. MDPI 2020-12-23 /pmc/articles/PMC7794712/ /pubmed/33374878 http://dx.doi.org/10.3390/polym13010029 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoon, Seung Kyun
Yang, Jin Ho
Lim, Hyun Tae
Chang, Young-Wook
Ayyoob, Muhammad
Yang, Xin
Kim, Young Jun
Ko, Han-Seung
Jho, Jae Young
Chung, Dong June
In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation
title In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation
title_full In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation
title_fullStr In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation
title_full_unstemmed In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation
title_short In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation
title_sort in vitro and in vivo biosafety analysis of resorbable polyglycolic acid-polylactic acid block copolymer composites for spinal fixation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794712/
https://www.ncbi.nlm.nih.gov/pubmed/33374878
http://dx.doi.org/10.3390/polym13010029
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