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Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study

Background: This study aimed to evaluate the association between sex and clinical outcomes in patients with coronavirus disease (COVID-19) using a population-based dataset. Methods: In this retrospective study, insurance claims data from the Korea database were used. Patients who tested positive for...

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Autores principales: Cho, Kyu Hyang, Kim, Sang Won, Park, Jong Won, Do, Jun Young, Kang, Seok Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794723/
https://www.ncbi.nlm.nih.gov/pubmed/33374452
http://dx.doi.org/10.3390/jcm10010038
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author Cho, Kyu Hyang
Kim, Sang Won
Park, Jong Won
Do, Jun Young
Kang, Seok Hui
author_facet Cho, Kyu Hyang
Kim, Sang Won
Park, Jong Won
Do, Jun Young
Kang, Seok Hui
author_sort Cho, Kyu Hyang
collection PubMed
description Background: This study aimed to evaluate the association between sex and clinical outcomes in patients with coronavirus disease (COVID-19) using a population-based dataset. Methods: In this retrospective study, insurance claims data from the Korea database were used. Patients who tested positive for COVID-19 were included in the study. All diseases were defined according to the International Classification of Diseases 10th revision. During follow-up, the clinical outcomes, except mortality, were assessed using the electrical codes from the dataset. The clinical outcomes noted were: hospitalization, the use of inotropics, high flow nasal cannula, conventional oxygen therapy, mechanical ventilation, extracorporeal membrane oxygenation, development of acute kidney injury, cardiac arrest, myocardial infarction, acute heart failure, pulmonary embolism, and disseminated intravascular coagulation after the diagnosis of COVID-19. Results: A total of 7327 patients were included; of these, 2964 patients (40.5%) were men and 4363 patients (59.5%) were women. There were no significant differences in the Charlson comorbidity index score between men and women in the same age group. The incidence of mortality and clinical outcomes was higher among men than among women. The mortality rate was the highest for the populations aged 50–64 or ≥65 years. The subgroup analyses for age, diabetes mellitus, or hypertension showed favorable results for patient survival or clinical outcomes for women compared to men. Conclusion: Our population-based study showed that female patients with COVID-19 were associated with favorable outcomes. Furthermore, the impact of sex was more evident in patients aged 50–64 or ≥65 years.
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spelling pubmed-77947232021-01-10 Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study Cho, Kyu Hyang Kim, Sang Won Park, Jong Won Do, Jun Young Kang, Seok Hui J Clin Med Article Background: This study aimed to evaluate the association between sex and clinical outcomes in patients with coronavirus disease (COVID-19) using a population-based dataset. Methods: In this retrospective study, insurance claims data from the Korea database were used. Patients who tested positive for COVID-19 were included in the study. All diseases were defined according to the International Classification of Diseases 10th revision. During follow-up, the clinical outcomes, except mortality, were assessed using the electrical codes from the dataset. The clinical outcomes noted were: hospitalization, the use of inotropics, high flow nasal cannula, conventional oxygen therapy, mechanical ventilation, extracorporeal membrane oxygenation, development of acute kidney injury, cardiac arrest, myocardial infarction, acute heart failure, pulmonary embolism, and disseminated intravascular coagulation after the diagnosis of COVID-19. Results: A total of 7327 patients were included; of these, 2964 patients (40.5%) were men and 4363 patients (59.5%) were women. There were no significant differences in the Charlson comorbidity index score between men and women in the same age group. The incidence of mortality and clinical outcomes was higher among men than among women. The mortality rate was the highest for the populations aged 50–64 or ≥65 years. The subgroup analyses for age, diabetes mellitus, or hypertension showed favorable results for patient survival or clinical outcomes for women compared to men. Conclusion: Our population-based study showed that female patients with COVID-19 were associated with favorable outcomes. Furthermore, the impact of sex was more evident in patients aged 50–64 or ≥65 years. MDPI 2020-12-24 /pmc/articles/PMC7794723/ /pubmed/33374452 http://dx.doi.org/10.3390/jcm10010038 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cho, Kyu Hyang
Kim, Sang Won
Park, Jong Won
Do, Jun Young
Kang, Seok Hui
Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study
title Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study
title_full Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study
title_fullStr Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study
title_full_unstemmed Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study
title_short Effect of Sex on Clinical Outcomes in Patients with Coronavirus Disease: A Population-Based Study
title_sort effect of sex on clinical outcomes in patients with coronavirus disease: a population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794723/
https://www.ncbi.nlm.nih.gov/pubmed/33374452
http://dx.doi.org/10.3390/jcm10010038
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