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Multiple Recombination Events and Strong Purifying Selection at the Origin of SARS-CoV-2 Spike Glycoprotein Increased Correlated Dynamic Movements
Our evolutionary and structural analyses revealed that the severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) spike gene is a complex mosaic resulting from several recombination events. Additionally, the fixation of variants has mainly been driven by purifying selection, suggesting...
Autores principales: | Tagliamonte, Massimiliano S., Abid, Nabil, Borocci, Stefano, Sangiovanni, Elisa, Ostrov, David A., Kosakovsky Pond, Sergei L., Salemi, Marco, Chillemi, Giovanni, Mavian, Carla |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794730/ https://www.ncbi.nlm.nih.gov/pubmed/33374797 http://dx.doi.org/10.3390/ijms22010080 |
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