Cargando…

Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression

Fenofibrate slows the progression of clinical diabetic retinopathy (DR), but its mechanism of action in the retina remains unclear. Fenofibrate is a known agonist of peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor critical for regulating metabolism, inflammation and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Enright, Jennifer M., Zhang, Sheng, Thebeau, Christina, Siebert, Emily, Jin, Alexander, Gadiraju, Veda, Zhang, Xiaodong, Chen, Shiming, Semenkovich, Clay F., Rajagopal, Rithwick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794763/ https://www.ncbi.nlm.nih.gov/pubmed/33396512 http://dx.doi.org/10.3390/jcm10010126

Ejemplares similares

Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision
por: Rajagopal, Rithwick, et al.
Publicado: (2018)

Altered Peroxisome Proliferator-Activated Receptor Alpha Signaling in Variably Diseased Peripheral Arterial Segments
por: Engel, Connor, et al.
Publicado: (2022)

Treatment of experimental autoimmune uveoretinitis with peroxisome proliferator-activated receptor α agonist fenofibrate
por: Osada, Miho, et al.
Publicado: (2014)

Glucose-mediated de novo lipogenesis in photoreceptors drives early diabetic retinopathy
por: Rajagopal, Rithwick, et al.
Publicado: (2021)

Quantification of retinal layer thickness changes in acute macular neuroretinopathy
por: Munk, Marion R, et al.
Publicado: (2017)

Acute Macular Neuroretinopathy in a Patient with Retinal Vascular Tortuosity
por: Karska-Basta, Izabella, et al.
Publicado: (2021)

Acute macular neuroretinopathy secondary to central retinal artery occlusion
por: Sarrasin, Emérentienne, et al.
Publicado: (2023)

The synergistic ameliorative activity of peroxisome proliferator‐activated receptor‐alpha and gamma agonists, fenofibrate and pioglitazone, on hippocampal neurodegeneration in a rat model of insulin resistance
por: Idowu, Olumayowa K., et al.
Publicado: (2022)

Peroxisome Proliferator–Activated Receptor-α Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia
por: Mulvey, Claire K., et al.
Publicado: (2012)

A patient with acute macular neuroretinopathy and central retinal vein occlusion
por: Hirooka, Kiriko, et al.
Publicado: (2013)

The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
por: Stunes, Astrid K, et al.
Publicado: (2011)

Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
por: Syversen, Unni, et al.
Publicado: (2009)

Fenofibrate, a peroxisome proliferator-activated receptor α-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver
por: Won, Tae Wan
Publicado: (2013)

Adaptation of peroxisome proliferator-activated receptor alpha to hibernation in bats
por: Han, Yijie, et al.
Publicado: (2015)

Peroxisome Proliferator-Activated Receptor Alpha Target Genes
por: Rakhshandehroo, Maryam, et al.
Publicado: (2010)

Twelve-Year-Old Girl with Acute Macular Neuroretinopathy: A Multimodal Retinal Evaluation
por: Nakayama, Luis Filipe, et al.
Publicado: (2020)

Acute Macular Neuroretinopathy in Purtscher Retinopathy
por: Şekeryapan Gediz, Berrak
Publicado: (2020)

Fenofibrate decreases radiation sensitivity via peroxisome proliferator-activated receptor α-mediated superoxide dismutase induction in HeLa cells
por: Liu, Xianguang, et al.
Publicado: (2012)

Acute macular neuroretinopathy with coexistent central retinal vein occlusion as the presenting feature in intraocular tuberculosis
por: Venkatesh, Ramesh, et al.
Publicado: (2020)

Multimodal imaging characteristics of acute macular neuroretinopathy
por: Saurabh, Kumar, et al.
Publicado: (2019)

Acute macular neuroretinopathy associated to dengue disease
por: Translateur, Amir, et al.
Publicado: (2022)

Acute Macular Neuroretinopathy Related to Alcoholic Hepatitis
por: Mc Cabe, Grace Anne, et al.
Publicado: (2021)

Acute macular neuroretinopathy and COVID-19 vaccination
por: Sanjay, Srinivasan, et al.
Publicado: (2022)

COVID-19-assoziierte akute makuläre Neuroretinopathie
por: Strzalkowski, P., et al.
Publicado: (2022)

Acute Macular Neuroretinopathy and Coronavirus Disease 2019
por: Dinh, Russel H., et al.
Publicado: (2023)

The Peroxisome Proliferator-Activated Receptor (PPAR) α Agonist Fenofibrate Suppresses Chemically Induced Lung Alveolar Proliferative Lesions in Male Obese Hyperlipidemic Mice
por: Kuno, Toshiya, et al.
Publicado: (2014)

Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice
por: Kong, Lingbo, et al.
Publicado: (2011)

Acute macular neuroretinopathy associated with acute promyelocytic leukemia
por: Thakar, Sudip D., et al.
Publicado: (2021)

Acute macular neuroretinopathy associated with COVID-19 infection
por: David, James A., et al.
Publicado: (2021)

Acute macular neuroretinopathy in dengue virus serotype 1
por: Guardiola, Gabriel A., et al.
Publicado: (2022)

Acute macular neuroretinopathy following COVID-19 vaccination
por: Bøhler, Anders Djupesland, et al.
Publicado: (2021)

Acute macular neuroretinopathy after COVID-19 vaccine
por: Michel, T., et al.
Publicado: (2022)

COVID-19 and Acute Macular Neuroretinopathy – An underlying association?
por: Ahmed, Warda, et al.
Publicado: (2022)

Mechanisms Involved in the Enhanced Susceptibility of Senescent Rats to the Hepatocarcinogenic Effect of Peroxisome Proliferators: Role of Peroxisome Proliferator-Activated Receptor alpha (PPAR), Cell Proliferation and Oxidative Stress
por: Youssef, Jihan A., et al.
Publicado: (2001)

Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) in rats.
por: Reddy, J. K., et al.
Publicado: (1979)

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha
por: Li, Guolin, et al.
Publicado: (2017)

Hepatic Peroxisome Proliferator-Activated Receptor Alpha Dysfunction in Porcine Septic Shock
por: Vandewalle, Jolien, et al.
Publicado: (2022)

Mechanistic insights into the peroxisome proliferator-activated receptor alpha as a transcriptional suppressor
por: Yagai, Tomoki, et al.
Publicado: (2022)

Branch Retinal Artery Occlusions, Paracentral Acute Middle Maculopathy and Acute Macular Neuroretinopathy After COVID-19 Vaccinations
por: Ishibashi, Koki, et al.
Publicado: (2022)

Tozinameran: Branch retinal artery occlusions, paracentral acute middle maculopathy and acute macular neuroretinopathy: 6 case reports
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ilfmfppgh86pntduifpb3vejfi