Iron Chelation in Local Infection

Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This ph...

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Detalles Bibliográficos
Autores principales: Scott, Cassidy, Arora, Gaurav, Dickson, Kayle, Lehmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794793/
https://www.ncbi.nlm.nih.gov/pubmed/33401708
http://dx.doi.org/10.3390/molecules26010189
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author Scott, Cassidy
Arora, Gaurav
Dickson, Kayle
Lehmann, Christian
author_facet Scott, Cassidy
Arora, Gaurav
Dickson, Kayle
Lehmann, Christian
author_sort Scott, Cassidy
collection PubMed
description Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale for the therapeutic use of iron chelators to support induced iron deprivation and to treat infections. In this review paper we discuss the importance of iron regulation through examples of local infection and the potential of iron chelation in treating infection.
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spelling pubmed-77947932021-01-10 Iron Chelation in Local Infection Scott, Cassidy Arora, Gaurav Dickson, Kayle Lehmann, Christian Molecules Review Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale for the therapeutic use of iron chelators to support induced iron deprivation and to treat infections. In this review paper we discuss the importance of iron regulation through examples of local infection and the potential of iron chelation in treating infection. MDPI 2021-01-02 /pmc/articles/PMC7794793/ /pubmed/33401708 http://dx.doi.org/10.3390/molecules26010189 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scott, Cassidy
Arora, Gaurav
Dickson, Kayle
Lehmann, Christian
Iron Chelation in Local Infection
title Iron Chelation in Local Infection
title_full Iron Chelation in Local Infection
title_fullStr Iron Chelation in Local Infection
title_full_unstemmed Iron Chelation in Local Infection
title_short Iron Chelation in Local Infection
title_sort iron chelation in local infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794793/
https://www.ncbi.nlm.nih.gov/pubmed/33401708
http://dx.doi.org/10.3390/molecules26010189
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AT dicksonkayle ironchelationinlocalinfection
AT lehmannchristian ironchelationinlocalinfection

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