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GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice

The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatme...

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Detalles Bibliográficos
Autores principales: Biagetti, Betina, Simó, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795003/
https://www.ncbi.nlm.nih.gov/pubmed/33401779
http://dx.doi.org/10.3390/ijms22010415
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author Biagetti, Betina
Simó, Rafael
author_facet Biagetti, Betina
Simó, Rafael
author_sort Biagetti, Betina
collection PubMed
description The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field.
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spelling pubmed-77950032021-01-10 GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice Biagetti, Betina Simó, Rafael Int J Mol Sci Review The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field. MDPI 2021-01-02 /pmc/articles/PMC7795003/ /pubmed/33401779 http://dx.doi.org/10.3390/ijms22010415 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Biagetti, Betina
Simó, Rafael
GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
title GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
title_full GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
title_fullStr GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
title_full_unstemmed GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
title_short GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
title_sort gh/igf-1 abnormalities and muscle impairment: from basic research to clinical practice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795003/
https://www.ncbi.nlm.nih.gov/pubmed/33401779
http://dx.doi.org/10.3390/ijms22010415
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