Cargando…
GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatme...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795003/ https://www.ncbi.nlm.nih.gov/pubmed/33401779 http://dx.doi.org/10.3390/ijms22010415 |
_version_ | 1783634341683789824 |
---|---|
author | Biagetti, Betina Simó, Rafael |
author_facet | Biagetti, Betina Simó, Rafael |
author_sort | Biagetti, Betina |
collection | PubMed |
description | The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field. |
format | Online Article Text |
id | pubmed-7795003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77950032021-01-10 GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice Biagetti, Betina Simó, Rafael Int J Mol Sci Review The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field. MDPI 2021-01-02 /pmc/articles/PMC7795003/ /pubmed/33401779 http://dx.doi.org/10.3390/ijms22010415 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Biagetti, Betina Simó, Rafael GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice |
title | GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice |
title_full | GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice |
title_fullStr | GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice |
title_full_unstemmed | GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice |
title_short | GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice |
title_sort | gh/igf-1 abnormalities and muscle impairment: from basic research to clinical practice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795003/ https://www.ncbi.nlm.nih.gov/pubmed/33401779 http://dx.doi.org/10.3390/ijms22010415 |
work_keys_str_mv | AT biagettibetina ghigf1abnormalitiesandmuscleimpairmentfrombasicresearchtoclinicalpractice AT simorafael ghigf1abnormalitiesandmuscleimpairmentfrombasicresearchtoclinicalpractice |