Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

Prenatal smoke exposure (PreSE) is a risk factor for nicotine dependence, which is further enhanced by postnatal smoke exposure (PostSE). One susceptibility gene to nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine in the liver. Higher...

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Detalles Bibliográficos
Autores principales: Lkhagvadorj, Khosbayar, Zeng, Zhijun, Meyer, Karolin F., Verweij, Laura P., Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W., de Graaf, Inge A. M., Plösch, Torsten, Hylkema, Machteld N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795156/
https://www.ncbi.nlm.nih.gov/pubmed/33375250
http://dx.doi.org/10.3390/ijms22010164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795156/
https://www.ncbi.nlm.nih.gov/pubmed/33375250
http://dx.doi.org/10.3390/ijms22010164

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