Cargando…

Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer’s Disease, Lithium, and Autophagy

Lithium is the prototype mood-stabilizer used for acute and long-term treatment of bipolar disorder. Cumulated translational research of lithium indicated the drug’s neuroprotective characteristics and, thereby, has raised the option of repurposing it as a drug for neurodegenerative diseases. Lithiu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Damri, Odeya, Shemesh, Nofar, Agam, Galila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795249/ https://www.ncbi.nlm.nih.gov/pubmed/33375448 http://dx.doi.org/10.3390/ijms22010189

Ejemplares similares

The observed alteration in BCL2 expression following lithium treatment is influenced by the choice of normalization method
por: Odeya, Damri, et al.
Publicado: (2018)

Dual Role of Autophagy in Diseases of the Central Nervous System
por: Bar-Yosef, Tamara, et al.
Publicado: (2019)

Do Autophagy Enhancers/ROS Scavengers Alleviate Consequences of Mild Mitochondrial Dysfunction Induced in Neuronal-Derived Cells?
por: Odeya, Damri, et al.
Publicado: (2021)

The Effect of Global Warming on Complex Disorders (Mental Disorders, Primary Hypertension, and Type 2 Diabetes)
por: Natur, Sarya, et al.
Publicado: (2022)

Neuroinflammation as a Common Denominator of Complex Diseases (Cancer, Diabetes Type 2, and Neuropsychiatric Disorders)
por: Asslih, Serena, et al.
Publicado: (2021)

Mitochondrial function parameters as a tool for tailored drug treatment of an individual with psychosis: a proof of concept study
por: Bar-Yosef, Tamara, et al.
Publicado: (2020)

Why lithium studies for ALS treatment should not be halted prematurely
por: Agam, Galila, et al.
Publicado: (2014)

Low-Dose Aspirin Augments the Anti-Inflammatory Effects of Low-Dose Lithium in Lipopolysaccharide-Treated Rats
por: Shvartsur, Rachel, et al.
Publicado: (2022)

Current Drug Repurposing Strategies for Rare Neurodegenerative Disorders
por: Shah, Sweta, et al.
Publicado: (2021)

Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders()
por: Khatri, Dharmendra Kumar, et al.
Publicado: (2021)

Does treatment with autophagy-enhancers and/or ROS-scavengers alleviate behavioral and neurochemical consequences of low-dose rotenone-induced mild mitochondrial dysfunction in mice?
por: Damri, O., et al.
Publicado: (2023)

Repurposing Immunomodulatory Imide Drugs (IMiDs) in Neuropsychiatric and Neurodegenerative Disorders
por: Jung, Yoo Jin, et al.
Publicado: (2021)

An Overview of the Neurotrophic and Neuroprotective Properties of the Psychoactive Drug Lithium as an Autophagy Modulator in Neurodegenerative Conditions
por: Singh, Ajay, et al.
Publicado: (2023)

Using mitochondrial respiration inhibitors to design a novel model of bipolar disorder-like phenotype with construct, face and predictive validity
por: Damri, O., et al.
Publicado: (2021)

Autophagy and neurodegenerative disorders
por: Kesidou, Evangelia, et al.
Publicado: (2013)

Lithium Treatment Is Safe in Children With Intellectual Disability
por: Yuan, Junying, et al.
Publicado: (2018)

Overcoming obstacles to repurposing for neurodegenerative disease
por: Shineman, Diana W, et al.
Publicado: (2014)

Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
por: Toker, Lilach, et al.
Publicado: (2015)

The justification of induction
Publicado: (1974)

Knowledge and justification /
Publicado: (1994)

Perspective insights of repurposing the pleiotropic efficacy of statins in neurodegenerative disorders: An expository appraisal
por: Bhat, Aditi, et al.
Publicado: (2020)

Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?
por: Lordén, Gema, et al.
Publicado: (2021)

Finding Drug Repurposing Candidates for Neurodegenerative Diseases using Zebrafish Behavioral Profiles
por: Hernández, Thaís Del Rosario, et al.
Publicado: (2023)

Systems Biology Understanding of the Effects of Lithium on Affective and Neurodegenerative Disorders
por: Ge, Weihao, et al.
Publicado: (2018)

In silico repurposing of antipsychotic drugs for Alzheimer’s disease
por: Kumar, Shivani, et al.
Publicado: (2017)

Drug repurposing candidates to treat core symptoms in autism spectrum disorder
por: Koch, Elise, et al.
Publicado: (2022)

Assessing System Justification in Czech Population Using the System Justification Scale
por: Remr, Jiri
Publicado: (2023)

Individual differences and evidence-based psychopharmacology
por: Belmaker, RH, et al.
Publicado: (2012)

Repurposing drugs to treat neurological diseases
por: Massey, T. H., et al.
Publicado: (2018)

Safety and Efficacy of Combined Low-Dose Lithium and Low-Dose Aspirin: A Pharmacological and Behavioral Proof-of-Concept Study in Rats
por: Shvartsur, Rachel, et al.
Publicado: (2021)

The justification of scientific change
por: Kordig, Carl R.
Publicado: (1971)

Basic Salaries - Justification
Publicado: (1955)

Physics'Justification for LEP
Publicado: (1979)

Physics'Justification for LEP
Publicado: (1979)

Is there justification for universal leukoreduction?
por: Mendrone, Alfredo, et al.
Publicado: (2014)

The logic of epistemic justification
por: Smith, Martin
Publicado: (2017)

Graded epistemic justification
por: Hawthorne, John, et al.
Publicado: (2020)

The System Justification Conundrum: Re-Examining the Cognitive Dissonance Basis for System Justification
por: Owuamalam, Chuma K., et al.
Publicado: (2016)

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease
por: Araki, Wataru
Publicado: (2013)

Repurposed agents in the Alzheimer’s disease drug development pipeline
por: Bauzon, Justin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cj12d11l8o5psj6tj4jmdu4esm