Cargando…

Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression

We previously reported that site-selective claudin-5 (CLDN5) breakdown and protein kinase A (PKA) activation are observed in brain microvessels of schizophrenia, but the underlying molecular basis remains unknown. The 5-HT1 receptors decline the intracellular cAMP levels and inactivate the major dow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sugimoto, Kotaro, Ichikawa-Tomikawa, Naoki, Nishiura, Keisuke, Kunii, Yasuto, Sano, Yasuteru, Shimizu, Fumitaka, Kakita, Akiyoshi, Kanda, Takashi, Imura, Tetsuya, Chiba, Hideki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795278/ https://www.ncbi.nlm.nih.gov/pubmed/33383868 http://dx.doi.org/10.3390/ijms22010254

Ejemplares similares

PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex
por: Nishiura, Keisuke, et al.
Publicado: (2017)

The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling
por: Ichikawa-Tomikawa, Naoki, et al.
Publicado: (2023)

Possible Involvement of Tight Junctions, Extracellular Matrix and Nuclear Receptors in Epithelial Differentiation
por: Ichikawa-Tomikawa, Naoki, et al.
Publicado: (2011)

Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
por: Neumann, Joachim, et al.
Publicado: (2023)

Conservation of 5-HT(1A) receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
por: Araragi, Naozumi, et al.
Publicado: (2013)

Azologization of serotonin 5-HT(3) receptor antagonists
por: Rustler, Karin, et al.
Publicado: (2019)

Biophysical validation of serotonin 5-HT(2A) and 5-HT(2C) receptor interaction
por: Felsing, Daniel E., et al.
Publicado: (2018)

Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT(3A) and 5-HT(6) receptor subtypes
por: Vitalis, Tania, et al.
Publicado: (2013)

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT(2A) and 5-HT(2B) receptors in chondrocytes
por: Hori, Ayaka, et al.
Publicado: (2017)

Serotonin 5-HT(2A )and 5-HT(6 )receptors in the prefrontal cortex of Alzheimer and normal aging patients
por: Lorke, Dietrich E, et al.
Publicado: (2006)

5HT(2A) and 5HT(2B) Receptors Contribute to Serotonin-Induced Vascular Dysfunction in Diabetes
por: Nelson, Peter M., et al.
Publicado: (2012)

5-HT(2A), 5-HT(1B/D), 5HT(3) and 5-HT(7) receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle
por: Da Costa Guevara, Darwin, et al.
Publicado: (2021)

Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development
por: Nikolić, Jelena, et al.
Publicado: (2023)

Soluble JAM-C Ectodomain Serves as the Niche for Adipose-Derived Stromal/Stem Cells
por: Yamazaki, Morio, et al.
Publicado: (2021)

Reduction of the serotonin 5-HT(1B) and 5-HT(2A) receptor-mediated contraction of human pulmonary artery by the combined 5-HT(1B) receptor antagonist and serotonin transporter inhibitor LY393558
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2020)

CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma
por: Watanabe, Masayuki, et al.
Publicado: (2021)

Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
por: González-Hernández, Abimael, et al.
Publicado: (2023)

Polymorphism of the CLDN5 gene and Schizophrenia in an Iranian Population
por: OMIDINIA, Eskandar, et al.
Publicado: (2014)

Variation within the serotonin (5-HT) 5-HT(2C) receptor system aligns with vulnerability to cocaine cue reactivity
por: Anastasio, N C, et al.
Publicado: (2014)

The role of the serotonin receptor subtypes 5-HT(1A) and 5-HT(7) and its interaction in emotional learning and memory
por: Stiedl, Oliver, et al.
Publicado: (2015)

The serotonin 5-HT3 receptor: a novel neurodevelopmental target
por: Engel, Mareen, et al.
Publicado: (2013)

The role of serotonin 5-HT(2A) receptors in memory and cognition
por: Zhang, Gongliang, et al.
Publicado: (2015)

Allosteric Inhibition of Serotonin 5-HT(7) Receptors by Zinc Ions
por: Satała, Grzegorz, et al.
Publicado: (2017)

Alterations of Expression of the Serotonin 5-HT4 Receptor in Brain Disorders
por: Rebholz, Heike, et al.
Publicado: (2018)

Mechanistic Studies on the Stereoselectivity of the Serotonin 5‐HT(1A) Receptor
por: Yuan, Shuguang, et al.
Publicado: (2016)

Comparative analysis of palmitoylation sites of serotonin (5‐HT) receptors in vertebrates
por: Kaizuka, Toshie, et al.
Publicado: (2018)

New Triazine Derivatives as Serotonin 5-HT(6) Receptor Ligands
por: Łażewska, Dorota, et al.
Publicado: (2023)

Changes of Serotonin (5-HT), 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression
por: Liu, Mei-Yan, et al.
Publicado: (2015)

Molecular and Pharmacological Characterization of Serotonin 5-HT(2α) and 5-HT(7) Receptors in the Salivary Glands of the Blowfly Calliphora vicina
por: Röser, Claudia, et al.
Publicado: (2012)

Maternal feeding patterns affect the offspring’s brain: focus on serotonin 5-HT(2C) and 5-HT(2A) receptors
por: Gawlińska, Kinga, et al.
Publicado: (2021)

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR
por: Zilberg, Gregory, et al.
Publicado: (2023)

The CLDN5 gene at the blood-brain barrier in health and disease
por: Hashimoto, Yosuke, et al.
Publicado: (2023)

Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat
por: Huang, Yuejun, et al.
Publicado: (2012)

Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor
por: Mancia, Filippo, et al.
Publicado: (2008)

Serotonin Augments Gut Pacemaker Activity via 5-HT(3) Receptors
por: Liu, Hong-Nian, et al.
Publicado: (2011)

Effect of the 5-HT(4) receptor and serotonin transporter on visceral hypersensitivity in rats
por: Chi, Yan, et al.
Publicado: (2012)

Development of Fluorescent Probes that Target Serotonin 5-HT(2B) Receptors
por: Azuaje, Jhonny, et al.
Publicado: (2017)

Serotonin 5-HT3 Receptor Antagonist for Treatment of Severe Diabetic Diarrhea
por: Murao, Satoshi, et al.
Publicado: (2010)

Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor
por: Lee, Jieon, et al.
Publicado: (2021)

Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures
por: Venzi, Marcello, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mvj41fptkn2inl4usssh8n44b2