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Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma

Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase of “marker” circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 p...

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Autores principales: Neroev, Vladimir, Malishevskaya, Tatyana, Weinert, Dietmar, Astakhov, Sergei, Kolomeichuk, Sergey, Cornelissen, Germaine, Kabitskaya, Yana, Boiko, Elena, Nemtsova, Irina, Gubin, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795318/
https://www.ncbi.nlm.nih.gov/pubmed/33396443
http://dx.doi.org/10.3390/ijms22010359
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author Neroev, Vladimir
Malishevskaya, Tatyana
Weinert, Dietmar
Astakhov, Sergei
Kolomeichuk, Sergey
Cornelissen, Germaine
Kabitskaya, Yana
Boiko, Elena
Nemtsova, Irina
Gubin, Denis
author_facet Neroev, Vladimir
Malishevskaya, Tatyana
Weinert, Dietmar
Astakhov, Sergei
Kolomeichuk, Sergey
Cornelissen, Germaine
Kabitskaya, Yana
Boiko, Elena
Nemtsova, Irina
Gubin, Denis
author_sort Neroev, Vladimir
collection PubMed
description Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase of “marker” circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 participants (65 S-POAG and 50 A-POAG). Retinal Ganglion Cell (RGC) damage was assessed by high-definition optical coherence tomography. The 24-h IOP rhythm in A-POAG patients peaked during the night, opposite to the daytime phase position in S-POAG patients (p < 0.0001). The 24-h IOP phase correlated with RGC loss (p < 0.0001). The internal phase shift between IOP and body temperature gradually increased with POAG progression (p < 0.001). Angiotensin converting enzyme Alu-repeat deletion/insertion (ACE I/D) emerged as a candidate gene polymorphism, which may play a role in the alteration of the circadian IOP variability in advanced glaucoma. To conclude, a reliable estimation of the 24-h rhythm in IOP requires the degree of RGC damage to be assessed. In advanced POAG, the 24-h phase of IOP tended to occur during the night and correlated with RGC loss, being progressively delayed relative to the phase of temperature.
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spelling pubmed-77953182021-01-10 Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma Neroev, Vladimir Malishevskaya, Tatyana Weinert, Dietmar Astakhov, Sergei Kolomeichuk, Sergey Cornelissen, Germaine Kabitskaya, Yana Boiko, Elena Nemtsova, Irina Gubin, Denis Int J Mol Sci Article Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase of “marker” circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 participants (65 S-POAG and 50 A-POAG). Retinal Ganglion Cell (RGC) damage was assessed by high-definition optical coherence tomography. The 24-h IOP rhythm in A-POAG patients peaked during the night, opposite to the daytime phase position in S-POAG patients (p < 0.0001). The 24-h IOP phase correlated with RGC loss (p < 0.0001). The internal phase shift between IOP and body temperature gradually increased with POAG progression (p < 0.001). Angiotensin converting enzyme Alu-repeat deletion/insertion (ACE I/D) emerged as a candidate gene polymorphism, which may play a role in the alteration of the circadian IOP variability in advanced glaucoma. To conclude, a reliable estimation of the 24-h rhythm in IOP requires the degree of RGC damage to be assessed. In advanced POAG, the 24-h phase of IOP tended to occur during the night and correlated with RGC loss, being progressively delayed relative to the phase of temperature. MDPI 2020-12-31 /pmc/articles/PMC7795318/ /pubmed/33396443 http://dx.doi.org/10.3390/ijms22010359 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Neroev, Vladimir
Malishevskaya, Tatyana
Weinert, Dietmar
Astakhov, Sergei
Kolomeichuk, Sergey
Cornelissen, Germaine
Kabitskaya, Yana
Boiko, Elena
Nemtsova, Irina
Gubin, Denis
Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma
title Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma
title_full Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma
title_fullStr Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma
title_full_unstemmed Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma
title_short Disruption of 24-Hour Rhythm in Intraocular Pressure Correlates with Retinal Ganglion Cell Loss in Glaucoma
title_sort disruption of 24-hour rhythm in intraocular pressure correlates with retinal ganglion cell loss in glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795318/
https://www.ncbi.nlm.nih.gov/pubmed/33396443
http://dx.doi.org/10.3390/ijms22010359
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