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Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017

(1) Background: The health implications associated with the metabolically healthy obese (MHO) phenotype, in particular related to symptoms of depression, are still not clear. the purpose of this study is to check whether depression and metabolic status are relevant by classifying them into four grou...

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Autores principales: Seo, Yongseok, Lee, Seungyeon, Ahn, Joung-Sook, Min, Seongho, Kim, Min-Hyuk, Kim, Jang-Young, Kang, Dae Ryong, Hwang, Sangwon, Vicheka, Phor, Lee, Jinhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795335/
https://www.ncbi.nlm.nih.gov/pubmed/33374826
http://dx.doi.org/10.3390/ijerph18010063
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author Seo, Yongseok
Lee, Seungyeon
Ahn, Joung-Sook
Min, Seongho
Kim, Min-Hyuk
Kim, Jang-Young
Kang, Dae Ryong
Hwang, Sangwon
Vicheka, Phor
Lee, Jinhee
author_facet Seo, Yongseok
Lee, Seungyeon
Ahn, Joung-Sook
Min, Seongho
Kim, Min-Hyuk
Kim, Jang-Young
Kang, Dae Ryong
Hwang, Sangwon
Vicheka, Phor
Lee, Jinhee
author_sort Seo, Yongseok
collection PubMed
description (1) Background: The health implications associated with the metabolically healthy obese (MHO) phenotype, in particular related to symptoms of depression, are still not clear. the purpose of this study is to check whether depression and metabolic status are relevant by classifying them into four groups in accordance with the MHO diagnostic standard. Other impressions seen were the differences between sexes and the effects of the MHO on the occurrence of depression. (2) Methods: A sample of 3,586,492 adult individuals from the National Health Insurance Database of Korea was classified into four categories by their metabolic status and body mass index: (1) metabolically healthy non-obese (MHN); (2) metabolically healthy obese (MHO); (3) metabolically unhealthy non-obese (MUN); and (4) metabolically unhealthy obese (MUO). Participants were followed for six to eight years for new incidences of depression. The statistical significance of the general characteristics of the four groups, as well as the mean differences in metabolic syndrome risk factors, was assessed with the use of a one-way analysis of variance (ANOVA). (3) Results: The MHN ratio in women was higher than in men (men 39.3%, women 55.2%). In both men and women, depression incidence was the highest among MUO participants (odds ratio (OR) = 1.01 in men; OR = 1.09 in women). It was concluded as well that, among the risk factors of metabolic syndrome, waist circumference was the most related to depression. Among the four groups, the MUO phenotype was the most related to depression. Furthermore, in women participants, MHO is also related to a higher risk of depressive symptoms. These findings indicate that MHO is not a totally benign condition in relation to depression in women. (4) Conclusion: Therefore, reducing metabolic syndrome and obesity patients in Korea will likely reduce the incidence of depression.
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spelling pubmed-77953352021-01-10 Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017 Seo, Yongseok Lee, Seungyeon Ahn, Joung-Sook Min, Seongho Kim, Min-Hyuk Kim, Jang-Young Kang, Dae Ryong Hwang, Sangwon Vicheka, Phor Lee, Jinhee Int J Environ Res Public Health Article (1) Background: The health implications associated with the metabolically healthy obese (MHO) phenotype, in particular related to symptoms of depression, are still not clear. the purpose of this study is to check whether depression and metabolic status are relevant by classifying them into four groups in accordance with the MHO diagnostic standard. Other impressions seen were the differences between sexes and the effects of the MHO on the occurrence of depression. (2) Methods: A sample of 3,586,492 adult individuals from the National Health Insurance Database of Korea was classified into four categories by their metabolic status and body mass index: (1) metabolically healthy non-obese (MHN); (2) metabolically healthy obese (MHO); (3) metabolically unhealthy non-obese (MUN); and (4) metabolically unhealthy obese (MUO). Participants were followed for six to eight years for new incidences of depression. The statistical significance of the general characteristics of the four groups, as well as the mean differences in metabolic syndrome risk factors, was assessed with the use of a one-way analysis of variance (ANOVA). (3) Results: The MHN ratio in women was higher than in men (men 39.3%, women 55.2%). In both men and women, depression incidence was the highest among MUO participants (odds ratio (OR) = 1.01 in men; OR = 1.09 in women). It was concluded as well that, among the risk factors of metabolic syndrome, waist circumference was the most related to depression. Among the four groups, the MUO phenotype was the most related to depression. Furthermore, in women participants, MHO is also related to a higher risk of depressive symptoms. These findings indicate that MHO is not a totally benign condition in relation to depression in women. (4) Conclusion: Therefore, reducing metabolic syndrome and obesity patients in Korea will likely reduce the incidence of depression. MDPI 2020-12-23 2021-01 /pmc/articles/PMC7795335/ /pubmed/33374826 http://dx.doi.org/10.3390/ijerph18010063 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seo, Yongseok
Lee, Seungyeon
Ahn, Joung-Sook
Min, Seongho
Kim, Min-Hyuk
Kim, Jang-Young
Kang, Dae Ryong
Hwang, Sangwon
Vicheka, Phor
Lee, Jinhee
Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017
title Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017
title_full Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017
title_fullStr Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017
title_full_unstemmed Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017
title_short Association of Metabolically Healthy Obesity and Future Depression: Using National Health Insurance System Data in Korea from 2009–2017
title_sort association of metabolically healthy obesity and future depression: using national health insurance system data in korea from 2009–2017
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795335/
https://www.ncbi.nlm.nih.gov/pubmed/33374826
http://dx.doi.org/10.3390/ijerph18010063
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