Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction

Erectile Dysfunction (ED) is defined as the inability to maintain and/or achieve a satisfactory erection. This condition can be influenced by the presence of atherosclerosis, a systemic pathology of the vessels that also affects the cavernous arteries and which can cause an alteration of blood flow...

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Autores principales: Salvio, Gianmaria, Ciarloni, Alessandro, Cutini, Melissa, Balercia, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795368/
https://www.ncbi.nlm.nih.gov/pubmed/33401548
http://dx.doi.org/10.3390/ijms22010418
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author Salvio, Gianmaria
Ciarloni, Alessandro
Cutini, Melissa
Balercia, Giancarlo
author_facet Salvio, Gianmaria
Ciarloni, Alessandro
Cutini, Melissa
Balercia, Giancarlo
author_sort Salvio, Gianmaria
collection PubMed
description Erectile Dysfunction (ED) is defined as the inability to maintain and/or achieve a satisfactory erection. This condition can be influenced by the presence of atherosclerosis, a systemic pathology of the vessels that also affects the cavernous arteries and which can cause an alteration of blood flow at penile level. Among the cardiovascular risk factors affecting the genesis of atherosclerosis, hyperhomocysteinemia (HHcys) plays a central role, which is associated with oxidative stress and endothelial dysfunction. This review focuses on the biological processes that lead to homocysteine-induced endothelial damage and discusses the consequences of HHcys on male sexual function
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spelling pubmed-77953682021-01-10 Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction Salvio, Gianmaria Ciarloni, Alessandro Cutini, Melissa Balercia, Giancarlo Int J Mol Sci Review Erectile Dysfunction (ED) is defined as the inability to maintain and/or achieve a satisfactory erection. This condition can be influenced by the presence of atherosclerosis, a systemic pathology of the vessels that also affects the cavernous arteries and which can cause an alteration of blood flow at penile level. Among the cardiovascular risk factors affecting the genesis of atherosclerosis, hyperhomocysteinemia (HHcys) plays a central role, which is associated with oxidative stress and endothelial dysfunction. This review focuses on the biological processes that lead to homocysteine-induced endothelial damage and discusses the consequences of HHcys on male sexual function MDPI 2021-01-03 /pmc/articles/PMC7795368/ /pubmed/33401548 http://dx.doi.org/10.3390/ijms22010418 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Salvio, Gianmaria
Ciarloni, Alessandro
Cutini, Melissa
Balercia, Giancarlo
Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction
title Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction
title_full Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction
title_fullStr Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction
title_full_unstemmed Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction
title_short Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction
title_sort hyperhomocysteinemia: focus on endothelial damage as a cause of erectile dysfunction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795368/
https://www.ncbi.nlm.nih.gov/pubmed/33401548
http://dx.doi.org/10.3390/ijms22010418
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AT cutinimelissa hyperhomocysteinemiafocusonendothelialdamageasacauseoferectiledysfunction
AT balerciagiancarlo hyperhomocysteinemiafocusonendothelialdamageasacauseoferectiledysfunction

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