Cargando…

Transcriptomic Changes of Murine Visceral Fat Exposed to Intermittent Hypoxia at Single Cell Resolution

Intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea (OSA) and induces metabolic dysfunction manifesting as inflammation, increased lipolysis and insulin resistance in visceral white adipose tissues (vWAT). However, the cell types and their corresponding transcriptional pathways underl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khalyfa, Abdelnaby, Warren, Wesley, Andrade, Jorge, Bottoms, Christopher A., Rice, Edward S., Cortese, Rene, Kheirandish-Gozal, Leila, Gozal, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795619/ https://www.ncbi.nlm.nih.gov/pubmed/33383883 http://dx.doi.org/10.3390/ijms22010261

Ejemplares similares

Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation
por: Cortese, Rene, et al.
Publicado: (2015)

Cell-Selective Altered Cargo Properties of Extracellular Vesicles Following In Vitro Exposures to Intermittent Hypoxia
por: Sanz-Rubio, David, et al.
Publicado: (2021)

Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic Dysfunction
por: Khalyfa, Abdelnaby, et al.
Publicado: (2018)

Plasma Extracellular Vesicles in Children with OSA Disrupt Blood–Brain Barrier Integrity and Endothelial Cell Wound Healing In Vitro
por: Khalyfa, Abdelnaby, et al.
Publicado: (2019)

Circulating exosomes and gut microbiome induced insulin resistance in mice exposed to intermittent hypoxia: Effects of physical activity
por: Khalyfa, Abdelnaby, et al.
Publicado: (2021)

Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia
por: Cortese, Rene, et al.
Publicado: (2014)

Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein‐Associated Phospholipase A2 Plasma Activity Levels
por: Kheirandish‐Gozal, Leila, et al.
Publicado: (2017)

Plasma Exosomes and Improvements in Endothelial Function by Angiotensin 2 Type 1 Receptor or Cyclooxygenase 2 Blockade following Intermittent Hypoxia
por: Khalyfa, Abdelnaby, et al.
Publicado: (2017)

Explicit memory, anxiety and depressive like behavior in mice exposed to chronic intermittent hypoxia, sleep fragmentation, or both during the daylight period
por: Puech, Clementine, et al.
Publicado: (2022)

Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins
por: Gemel, Joanna, et al.
Publicado: (2017)

Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea
por: Chatsuriyawong, Siriporn, et al.
Publicado: (2013)

Microarray-based analysis of plasma cirDNA epigenetic modification profiling in xenografted mice exposed to intermittent hypoxia
por: Cortese, Rene, et al.
Publicado: (2015)

Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children
por: Kim, Jinkwan, et al.
Publicado: (2010)

Angiopoietin 2 and Soluble Tie-2 Receptor Plasma Levels in Children with Obstructive Sleep Apnea and Obesity
por: Gozal, David, et al.
Publicado: (2017)

Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36
por: Cortese, Rene, et al.
Publicado: (2017)

Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels
por: Khalyfa, Abdelnaby, et al.
Publicado: (2010)

Genetic variance in Nitric Oxide Synthase and Endothelin Genes among children with and without Endothelial Dysfunction
por: Chatsuriyawong, Siriporn, et al.
Publicado: (2013)

Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
por: Khalyfa, Abdelnaby, et al.
Publicado: (2014)

Cardiovascular morbidities of obstructive sleep apnea and the role of circulating extracellular vesicles
por: Khalyfa, Abdelnaby, et al.
Publicado: (2019)

Childhood obesity and sleep: relatives, partners, or both?—a critical perspective on the evidence
por: Gozal, David, et al.
Publicado: (2012)

Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines
por: Kheirandish-Gozal, Leila, et al.
Publicado: (2019)

Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules
por: Khalyfa, Abdelnaby, et al.
Publicado: (2017)

Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis
por: Khalyfa, Abdelnaby, et al.
Publicado: (2021)

Sleep Fragmentation During Late Gestation Induces Metabolic Perturbations and Epigenetic Changes in Adiponectin Gene Expression in Male Adult Offspring Mice
por: Khalyfa, Abdelnaby, et al.
Publicado: (2014)

Effects of Late Gestational High Fat Diet on Body Weight, Metabolic Regulation and Adipokine Expression in Offspring
por: Khalyfa, Abdelnaby, et al.
Publicado: (2013)

Heterogeneity of Melanoma Cell Responses to Sleep Apnea-Derived Plasma Exosomes and to Intermittent Hypoxia
por: Khalyfa, Abdelnaby, et al.
Publicado: (2021)

Sympathetic and Catecholaminergic Alterations in Sleep Apnea with Particular Emphasis on Children
por: Hakim, Fahed, et al.
Publicado: (2012)

The Endothelium as a Target in Pediatric OSA
por: Kheirandish-Gozal, Leila
Publicado: (2012)

Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia
por: Gharib, Sina A, et al.
Publicado: (2011)

Integrative miRNA-mRNA Profiling of Adipose Tissue Unravels Transcriptional Circuits Induced by Sleep Fragmentation
por: Gharib, Sina A., et al.
Publicado: (2012)

Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues
por: Khalyfa, Abdelnaby, et al.
Publicado: (2020)

Obstructive sleep apnea in children: a critical update
por: Tan, Hui-Leng, et al.
Publicado: (2013)

Inflammation in Sleep Debt and Sleep Disorders
por: Kheirandish-Gozal, Leila, et al.
Publicado: (2015)

Treatment of Obstructive Sleep Apnea in Children: Handling the Unknown with Precision
por: Gozal, David, et al.
Publicado: (2020)

Intermittent Hypoxia-Induced Cognitive Deficits Are Mediated by NADPH Oxidase Activity in a Murine Model of Sleep Apnea
por: Nair, Deepti, et al.
Publicado: (2011)

Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea
por: Dayyat, Ehab A, et al.
Publicado: (2012)

Intermittent Hypoxia Severity in Animal Models of Sleep Apnea
por: Farré, Ramon, et al.
Publicado: (2018)

Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea
por: Vilaseca, Antoni, et al.
Publicado: (2017)

Hypoxia differently modulates the release of mitochondrial and nuclear DNA
por: Otandault, Amaelle, et al.
Publicado: (2020)

Sleep-Disordered Breathing, Circulating Exosomes, and Insulin Sensitivity in Adipocytes
por: Khalyfa, Abdelnaby, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fl6rnmq6o9semamtslr7n78rhf