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Oxygen Saturation Imaging Using LED-Based Photoacoustic System

Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate i...

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Autores principales: Bulsink, Rianne, Kuniyil Ajith Singh, Mithun, Xavierselvan, Marvin, Mallidi, Srivalleesha, Steenbergen, Wiendelt, Francis, Kalloor Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795655/
https://www.ncbi.nlm.nih.gov/pubmed/33406653
http://dx.doi.org/10.3390/s21010283
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author Bulsink, Rianne
Kuniyil Ajith Singh, Mithun
Xavierselvan, Marvin
Mallidi, Srivalleesha
Steenbergen, Wiendelt
Francis, Kalloor Joseph
author_facet Bulsink, Rianne
Kuniyil Ajith Singh, Mithun
Xavierselvan, Marvin
Mallidi, Srivalleesha
Steenbergen, Wiendelt
Francis, Kalloor Joseph
author_sort Bulsink, Rianne
collection PubMed
description Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6–8 mm in both preclinical and clinical applications.
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spelling pubmed-77956552021-01-10 Oxygen Saturation Imaging Using LED-Based Photoacoustic System Bulsink, Rianne Kuniyil Ajith Singh, Mithun Xavierselvan, Marvin Mallidi, Srivalleesha Steenbergen, Wiendelt Francis, Kalloor Joseph Sensors (Basel) Article Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6–8 mm in both preclinical and clinical applications. MDPI 2021-01-04 /pmc/articles/PMC7795655/ /pubmed/33406653 http://dx.doi.org/10.3390/s21010283 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Bulsink, Rianne
Kuniyil Ajith Singh, Mithun
Xavierselvan, Marvin
Mallidi, Srivalleesha
Steenbergen, Wiendelt
Francis, Kalloor Joseph
Oxygen Saturation Imaging Using LED-Based Photoacoustic System
title Oxygen Saturation Imaging Using LED-Based Photoacoustic System
title_full Oxygen Saturation Imaging Using LED-Based Photoacoustic System
title_fullStr Oxygen Saturation Imaging Using LED-Based Photoacoustic System
title_full_unstemmed Oxygen Saturation Imaging Using LED-Based Photoacoustic System
title_short Oxygen Saturation Imaging Using LED-Based Photoacoustic System
title_sort oxygen saturation imaging using led-based photoacoustic system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795655/
https://www.ncbi.nlm.nih.gov/pubmed/33406653
http://dx.doi.org/10.3390/s21010283
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