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Oxygen Saturation Imaging Using LED-Based Photoacoustic System
Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795655/ https://www.ncbi.nlm.nih.gov/pubmed/33406653 http://dx.doi.org/10.3390/s21010283 |
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author | Bulsink, Rianne Kuniyil Ajith Singh, Mithun Xavierselvan, Marvin Mallidi, Srivalleesha Steenbergen, Wiendelt Francis, Kalloor Joseph |
author_facet | Bulsink, Rianne Kuniyil Ajith Singh, Mithun Xavierselvan, Marvin Mallidi, Srivalleesha Steenbergen, Wiendelt Francis, Kalloor Joseph |
author_sort | Bulsink, Rianne |
collection | PubMed |
description | Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6–8 mm in both preclinical and clinical applications. |
format | Online Article Text |
id | pubmed-7795655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77956552021-01-10 Oxygen Saturation Imaging Using LED-Based Photoacoustic System Bulsink, Rianne Kuniyil Ajith Singh, Mithun Xavierselvan, Marvin Mallidi, Srivalleesha Steenbergen, Wiendelt Francis, Kalloor Joseph Sensors (Basel) Article Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6–8 mm in both preclinical and clinical applications. MDPI 2021-01-04 /pmc/articles/PMC7795655/ /pubmed/33406653 http://dx.doi.org/10.3390/s21010283 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Bulsink, Rianne Kuniyil Ajith Singh, Mithun Xavierselvan, Marvin Mallidi, Srivalleesha Steenbergen, Wiendelt Francis, Kalloor Joseph Oxygen Saturation Imaging Using LED-Based Photoacoustic System |
title | Oxygen Saturation Imaging Using LED-Based Photoacoustic System |
title_full | Oxygen Saturation Imaging Using LED-Based Photoacoustic System |
title_fullStr | Oxygen Saturation Imaging Using LED-Based Photoacoustic System |
title_full_unstemmed | Oxygen Saturation Imaging Using LED-Based Photoacoustic System |
title_short | Oxygen Saturation Imaging Using LED-Based Photoacoustic System |
title_sort | oxygen saturation imaging using led-based photoacoustic system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795655/ https://www.ncbi.nlm.nih.gov/pubmed/33406653 http://dx.doi.org/10.3390/s21010283 |
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