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Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop

Taro corms contain valuable bioactive molecules effective against cancer and cancer-related risk factors, such as carcinogens and biological agents, several pathophysiological conditions, including oxidative stress and inflammation, while controlling metabolic dysfunctions and boosting the immunolog...

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Autores principales: Ribeiro Pereira, Patrícia, Bertozzi de Aquino Mattos, Érika, Nitzsche Teixeira Fernandes Corrêa, Anna Carolina, Afonso Vericimo, Mauricio, Margaret Flosi Paschoalin, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795958/
https://www.ncbi.nlm.nih.gov/pubmed/33383887
http://dx.doi.org/10.3390/ijms22010265
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author Ribeiro Pereira, Patrícia
Bertozzi de Aquino Mattos, Érika
Nitzsche Teixeira Fernandes Corrêa, Anna Carolina
Afonso Vericimo, Mauricio
Margaret Flosi Paschoalin, Vania
author_facet Ribeiro Pereira, Patrícia
Bertozzi de Aquino Mattos, Érika
Nitzsche Teixeira Fernandes Corrêa, Anna Carolina
Afonso Vericimo, Mauricio
Margaret Flosi Paschoalin, Vania
author_sort Ribeiro Pereira, Patrícia
collection PubMed
description Taro corms contain valuable bioactive molecules effective against cancer and cancer-related risk factors, such as carcinogens and biological agents, several pathophysiological conditions, including oxidative stress and inflammation, while controlling metabolic dysfunctions and boosting the immunological response. Such broad effects are achieved by the taro health-influencing compounds displaying antitumoral, antimutagenic, immunomodulatory, anti-inflammatory, antioxidant, anti-hyperglycemic, and anti-hyperlipidemic activities. Taro bioactivities are attributed to the combination of tarin, taro-4-I polysaccharide, taro polysaccharides 1 and 2 (TPS-1 and TPS-2), A-1/B-2 α-amylase inhibitors, monogalactosyldiacylglycerols (MGDGs), digalactosyldiacylglycerols (DGDGs), polyphenols, and nonphenolic antioxidants. Most of these compounds have been purified and successfully challenged in vitro and in vivo, proving their involvement in the aforementioned activities. Although these health-promoting effects have been recognized since ancient times, as well as other valuable features of taro for food profit, such as hypo-allergenicity, gluten-free, and carbohydrates with medium-glycemic index, taro crop remains underexploited. The popularization of taro intake should be considered a dietary intervention strategy to be applied to improve the overall health status of the organism and as supportive therapy to manage tumorigenesis.
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spelling pubmed-77959582021-01-10 Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop Ribeiro Pereira, Patrícia Bertozzi de Aquino Mattos, Érika Nitzsche Teixeira Fernandes Corrêa, Anna Carolina Afonso Vericimo, Mauricio Margaret Flosi Paschoalin, Vania Int J Mol Sci Review Taro corms contain valuable bioactive molecules effective against cancer and cancer-related risk factors, such as carcinogens and biological agents, several pathophysiological conditions, including oxidative stress and inflammation, while controlling metabolic dysfunctions and boosting the immunological response. Such broad effects are achieved by the taro health-influencing compounds displaying antitumoral, antimutagenic, immunomodulatory, anti-inflammatory, antioxidant, anti-hyperglycemic, and anti-hyperlipidemic activities. Taro bioactivities are attributed to the combination of tarin, taro-4-I polysaccharide, taro polysaccharides 1 and 2 (TPS-1 and TPS-2), A-1/B-2 α-amylase inhibitors, monogalactosyldiacylglycerols (MGDGs), digalactosyldiacylglycerols (DGDGs), polyphenols, and nonphenolic antioxidants. Most of these compounds have been purified and successfully challenged in vitro and in vivo, proving their involvement in the aforementioned activities. Although these health-promoting effects have been recognized since ancient times, as well as other valuable features of taro for food profit, such as hypo-allergenicity, gluten-free, and carbohydrates with medium-glycemic index, taro crop remains underexploited. The popularization of taro intake should be considered a dietary intervention strategy to be applied to improve the overall health status of the organism and as supportive therapy to manage tumorigenesis. MDPI 2020-12-29 /pmc/articles/PMC7795958/ /pubmed/33383887 http://dx.doi.org/10.3390/ijms22010265 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ribeiro Pereira, Patrícia
Bertozzi de Aquino Mattos, Érika
Nitzsche Teixeira Fernandes Corrêa, Anna Carolina
Afonso Vericimo, Mauricio
Margaret Flosi Paschoalin, Vania
Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
title Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
title_full Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
title_fullStr Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
title_full_unstemmed Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
title_short Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
title_sort anticancer and immunomodulatory benefits of taro (colocasia esculenta) corms, an underexploited tuber crop
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795958/
https://www.ncbi.nlm.nih.gov/pubmed/33383887
http://dx.doi.org/10.3390/ijms22010265
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