Cargando…

Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review

Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular s...

Descripción completa

Detalles Bibliográficos
Autores principales: Roşca, Adrian Eugen, Vlădăreanu, Ana-Maria, Mititelu, Alina, Popescu, Bogdan Ovidiu, Badiu, Corin, Căruntu, Constantin, Voiculescu, Suzana Elena, Onisâi, Minodora, Gologan, Şerban, Mirica, Radu, Zăgrean, Leon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795962/
https://www.ncbi.nlm.nih.gov/pubmed/33406783
http://dx.doi.org/10.3390/jcm10010147
_version_ 1783634568617656320
author Roşca, Adrian Eugen
Vlădăreanu, Ana-Maria
Mititelu, Alina
Popescu, Bogdan Ovidiu
Badiu, Corin
Căruntu, Constantin
Voiculescu, Suzana Elena
Onisâi, Minodora
Gologan, Şerban
Mirica, Radu
Zăgrean, Leon
author_facet Roşca, Adrian Eugen
Vlădăreanu, Ana-Maria
Mititelu, Alina
Popescu, Bogdan Ovidiu
Badiu, Corin
Căruntu, Constantin
Voiculescu, Suzana Elena
Onisâi, Minodora
Gologan, Şerban
Mirica, Radu
Zăgrean, Leon
author_sort Roşca, Adrian Eugen
collection PubMed
description Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid–coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential.
format Online
Article
Text
id pubmed-7795962
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-77959622021-01-10 Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review Roşca, Adrian Eugen Vlădăreanu, Ana-Maria Mititelu, Alina Popescu, Bogdan Ovidiu Badiu, Corin Căruntu, Constantin Voiculescu, Suzana Elena Onisâi, Minodora Gologan, Şerban Mirica, Radu Zăgrean, Leon J Clin Med Review Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid–coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential. MDPI 2021-01-04 /pmc/articles/PMC7795962/ /pubmed/33406783 http://dx.doi.org/10.3390/jcm10010147 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roşca, Adrian Eugen
Vlădăreanu, Ana-Maria
Mititelu, Alina
Popescu, Bogdan Ovidiu
Badiu, Corin
Căruntu, Constantin
Voiculescu, Suzana Elena
Onisâi, Minodora
Gologan, Şerban
Mirica, Radu
Zăgrean, Leon
Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
title Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
title_full Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
title_fullStr Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
title_full_unstemmed Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
title_short Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review
title_sort effects of exogenous androgens on platelet activity and their thrombogenic potential in supraphysiological administration: a literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795962/
https://www.ncbi.nlm.nih.gov/pubmed/33406783
http://dx.doi.org/10.3390/jcm10010147
work_keys_str_mv AT roscaadrianeugen effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT vladareanuanamaria effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT mititelualina effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT popescubogdanovidiu effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT badiucorin effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT caruntuconstantin effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT voiculescusuzanaelena effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT onisaiminodora effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT gologanserban effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT miricaradu effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview
AT zagreanleon effectsofexogenousandrogensonplateletactivityandtheirthrombogenicpotentialinsupraphysiologicaladministrationaliteraturereview