Cargando…

HIV-1 Tat Protein Enters Dysfunctional Endothelial Cells via Integrins and Renders Them Permissive to Virus Replication

Previous work has shown that the Tat protein of Human Immunodeficiency Virus (HIV)-1 is released by acutely infected cells in a biologically active form and enters dendritic cells upon the binding of its arginine-glycine-aspartic acid (RGD) domain to the α5β1, αvβ3, and αvβ5 integrins. The up-regula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cafaro, Aurelio, Barillari, Giovanni, Moretti, Sonia, Palladino, Clelia, Tripiciano, Antonella, Falchi, Mario, Picconi, Orietta, Pavone Cossut, Maria Rosaria, Campagna, Massimo, Arancio, Angela, Sgadari, Cecilia, Andreini, Claudia, Banci, Lucia, Monini, Paolo, Ensoli, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796023/ https://www.ncbi.nlm.nih.gov/pubmed/33396807 http://dx.doi.org/10.3390/ijms22010317

Ejemplares similares

Anti-Tat Immunity in HIV-1 Infection: Effects of Naturally Occurring and Vaccine-Induced Antibodies Against Tat on the Course of the Disease
por: Cafaro, Aurelio, et al.
Publicado: (2019)

New insights into pathogenesis point to HIV-1 Tat as a key vaccine target
por: Ensoli, Barbara, et al.
Publicado: (2021)

Anti-Tat immunity defines CD4(+) T-cell dynamics in people living with HIV on long-term cART.
por: Tripiciano, Antonella, et al.
Publicado: (2021)

Kaposi’s Sarcoma Lesion Progression in BKV-Tat Transgenic Mice Is Increased by Inflammatory Cytokines and Blocked by Treatment with Anti-Tat Antibodies
por: Brocca-Cofano, Egidio, et al.
Publicado: (2022)

HIV-Tat immunization induces cross-clade neutralizing antibodies and CD4(+) T cell increases in antiretroviral-treated South African volunteers: a randomized phase II clinical trial
por: Ensoli, Barbara, et al.
Publicado: (2016)

Continued Decay of HIV Proviral DNA Upon Vaccination With HIV-1 Tat of Subjects on Long-Term ART: An 8-Year Follow-Up Study
por: Sgadari, Cecilia, et al.
Publicado: (2019)

HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial
por: Ensoli, Fabrizio, et al.
Publicado: (2015)

HIV-1 Tat Promotes Integrin-Mediated HIV Transmission to Dendritic Cells by Binding Env Spikes and Competes Neutralization by Anti-HIV Antibodies
por: Monini, Paolo, et al.
Publicado: (2012)

Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma
por: Sgadari, Cecilia, et al.
Publicado: (2011)

Entrance of the Tat protein of HIV-1 into human uterine cervical carcinoma cells causes upregulation of HPV-E6 expression and a decrease in p53 protein levels
por: Barillari, Giovanni, et al.
Publicado: (2016)

The presence of anti-Tat antibodies in HIV-infected individuals is associated with containment of CD4(+) T-cell decay and viral load, and with delay of disease progression: results of a 3-year cohort study
por: Bellino, Stefania, et al.
Publicado: (2014)

The Impact of Human Papilloma Viruses, Matrix Metallo-Proteinases and HIV Protease Inhibitors on the Onset and Progression of Uterine Cervix Epithelial Tumors: A Review of Preclinical and Clinical Studies
por: Barillari, Giovanni, et al.
Publicado: (2018)

Inhibition of MMP-9 expression by ritonavir or saquinavir is associated with inactivation of the AKT/Fra-1 pathway in cervical intraepithelial neoplasia cells
por: Bacigalupo, Ilaria, et al.
Publicado: (2017)

Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART
por: Ensoli, Barbara, et al.
Publicado: (2010)

Biocompatible Anionic Polymeric Microspheres as Priming Delivery System for Effetive HIV/AIDS Tat-Based Vaccines
por: Titti, Fausto, et al.
Publicado: (2014)

Challenges in HIV Vaccine Research for Treatment and Prevention
por: Ensoli, Barbara, et al.
Publicado: (2014)

Defects in Innate Immunity Render Breast Cancer Initiating Cells Permissive to Oncolytic Adenovirus
por: Ahtiainen, Laura, et al.
Publicado: (2010)

HIV-1 Tat protein vaccination in mice infected with Mycobacterium tuberculosis is safe, immunogenic and reduces bacterial lung pathology
por: Cafaro, Aurelio, et al.
Publicado: (2016)

The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation
por: Nicoli, Francesco, et al.
Publicado: (2020)

Autophagy up-regulation upon FeHV-1 infection on permissive cells
por: Ferrara, Gianmarco, et al.
Publicado: (2023)

The HIV-1 Tat Protein Induces the Activation of CD8(+) T Cells and Affects In Vivo the Magnitude and Kinetics of Antiviral Responses
por: Nicoli, Francesco, et al.
Publicado: (2013)

Association between different anti-Tat antibody isotypes and HIV disease progression: data from an African cohort
por: Nicoli, Francesco, et al.
Publicado: (2016)

Induction of Antibodies and T Cell Responses by a Recombinant Influenza Virus Carrying an HIV-1 TatΔ(51–59) Protein in Mice
por: Garulli, B., et al.
Publicado: (2014)

An Attenuated Herpes Simplex Virus Type 1 (HSV1) Encoding the HIV-1 Tat Protein Protects Mice from a Deadly Mucosal HSV1 Challenge
por: Sicurella, Mariaconcetta, et al.
Publicado: (2014)

The Relationship between Environmental Dioxygen and Iron-Sulfur Proteins Explored at the Genome Level
por: Andreini, Claudia, et al.
Publicado: (2017)

Single cell analysis of the localization of the hematopoietic stem cells within the bone marrow architecture identifies niche-specific proliferation dynamics
por: Mazzarini, Maria, et al.
Publicado: (2023)

Permissive hypofiltration
por: Chawla, Lakhmir S, et al.
Publicado: (2012)

MetalPDB in 2018: a database of metal sites in biological macromolecular structures
por: Putignano, Valeria, et al.
Publicado: (2018)

Army liposome formulation containing QS-21 render human monocyte-derived macrophages less permissive to HIV-1 infection by upregulating APOBEC3A
por: Jobe, Ousman, et al.
Publicado: (2022)

TatBC-Independent TatA/Tat Substrate Interactions Contribute to Transport Efficiency
por: Taubert, Johannes, et al.
Publicado: (2015)

Growth behavior of bovine herpesvirus-1 in permissive and semi-permissive cells
por: Murata, Takayuki, et al.
Publicado: (1999)

Molecular Characterization of HIV-1 Subtype C gp-120 Regions Potentially Involved in Virus Adaptive Mechanisms
por: Cenci, Alessandra, et al.
Publicado: (2014)

Rendering for beginners: image synthesis using RenderMan
por: Raghavachary, Saty
Publicado: (2004)

On the Diseases of Animals Which Do Not Necessarily Render Them Unfit for the Food of Man
Publicado: (1880)

Fungal hydrophobins render stones impermeable for water but keep them permeable for vapor
por: Winandy, Lex, et al.
Publicado: (2019)

Permission to Speak Freely
por: Kincaid, Matt
Publicado: (2017)

How to achieve Tat transport with alien TatA
por: Hauer, René Steffen, et al.
Publicado: (2017)

ATLAS Rendered
Publicado: (2009)

Justice Rendered
Publicado: (1878)

For Services Rendered
Publicado: (1875)

Cannot write session to /tmp/vufind_sessions/sess_jg1ehn1941iqslshpa4s58lp27