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Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19

Background: Cardiac manifestation of COVID-19 has been reported during the COVID pandemic. The role of cardiac arrhythmias in COVID-19 is insufficiently understood. This study assesses the incidence of cardiac arrhythmias and their prognostic implications in hospitalized COVID-19-patients. Methods:...

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Autores principales: Zylla, Maura M., Merle, Uta, Vey, Johannes A., Korosoglou, Grigorios, Hofmann, Eva, Müller, Michael, Herth, Felix, Schmidt, Werner, Blessing, Erwin, Göggelmann, Christoph, Weidner, Norbert, Fiedler, Mascha O., Weigand, Markus A., Kälble, Florian, Morath, Christian, Leiner, Johannes, Kieser, Meinhard, Katus, Hugo A., Thomas, Dierk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796041/
https://www.ncbi.nlm.nih.gov/pubmed/33401735
http://dx.doi.org/10.3390/jcm10010133
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author Zylla, Maura M.
Merle, Uta
Vey, Johannes A.
Korosoglou, Grigorios
Hofmann, Eva
Müller, Michael
Herth, Felix
Schmidt, Werner
Blessing, Erwin
Göggelmann, Christoph
Weidner, Norbert
Fiedler, Mascha O.
Weigand, Markus A.
Kälble, Florian
Morath, Christian
Leiner, Johannes
Kieser, Meinhard
Katus, Hugo A.
Thomas, Dierk
author_facet Zylla, Maura M.
Merle, Uta
Vey, Johannes A.
Korosoglou, Grigorios
Hofmann, Eva
Müller, Michael
Herth, Felix
Schmidt, Werner
Blessing, Erwin
Göggelmann, Christoph
Weidner, Norbert
Fiedler, Mascha O.
Weigand, Markus A.
Kälble, Florian
Morath, Christian
Leiner, Johannes
Kieser, Meinhard
Katus, Hugo A.
Thomas, Dierk
author_sort Zylla, Maura M.
collection PubMed
description Background: Cardiac manifestation of COVID-19 has been reported during the COVID pandemic. The role of cardiac arrhythmias in COVID-19 is insufficiently understood. This study assesses the incidence of cardiac arrhythmias and their prognostic implications in hospitalized COVID-19-patients. Methods: A total of 166 patients from eight centers who were hospitalized for COVID-19 from 03/2020–06/2020 were included. Medical records were systematically analyzed for baseline characteristics, biomarkers, cardiac arrhythmias and clinical outcome parameters related to the index hospitalization. Predisposing risk factors for arrhythmias were identified. Furthermore, the influence of arrhythmia on the course of disease and related outcomes was assessed using univariate and multiple regression analyses. Results: Arrhythmias were detected in 20.5% of patients. Atrial fibrillation was the most common arrhythmia. Age and cardiovascular disease were predictors for new-onset arrhythmia. Arrhythmia was associated with a pronounced increase in cardiac biomarkers, prolonged hospitalization, and admission to intensive- or intermediate-care-units, mechanical ventilation and in-hospital mortality. In multiple regression analyses, incident arrhythmia was strongly associated with duration of hospitalization and mechanical ventilation. Cardiovascular disease was associated with increased mortality. Conclusions: Arrhythmia was the most common cardiac event in association with hospitalization for COVID-19. Older age and cardiovascular disease predisposed for arrhythmia during hospitalization. Whereas in-hospital mortality is affected by underlying cardiovascular conditions, arrhythmia during hospitalization for COVID-19 is independently associated with prolonged hospitalization and mechanical ventilation. Thus, incident arrhythmia may indicate a patient subgroup at risk for a severe course of disease.
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spelling pubmed-77960412021-01-10 Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19 Zylla, Maura M. Merle, Uta Vey, Johannes A. Korosoglou, Grigorios Hofmann, Eva Müller, Michael Herth, Felix Schmidt, Werner Blessing, Erwin Göggelmann, Christoph Weidner, Norbert Fiedler, Mascha O. Weigand, Markus A. Kälble, Florian Morath, Christian Leiner, Johannes Kieser, Meinhard Katus, Hugo A. Thomas, Dierk J Clin Med Article Background: Cardiac manifestation of COVID-19 has been reported during the COVID pandemic. The role of cardiac arrhythmias in COVID-19 is insufficiently understood. This study assesses the incidence of cardiac arrhythmias and their prognostic implications in hospitalized COVID-19-patients. Methods: A total of 166 patients from eight centers who were hospitalized for COVID-19 from 03/2020–06/2020 were included. Medical records were systematically analyzed for baseline characteristics, biomarkers, cardiac arrhythmias and clinical outcome parameters related to the index hospitalization. Predisposing risk factors for arrhythmias were identified. Furthermore, the influence of arrhythmia on the course of disease and related outcomes was assessed using univariate and multiple regression analyses. Results: Arrhythmias were detected in 20.5% of patients. Atrial fibrillation was the most common arrhythmia. Age and cardiovascular disease were predictors for new-onset arrhythmia. Arrhythmia was associated with a pronounced increase in cardiac biomarkers, prolonged hospitalization, and admission to intensive- or intermediate-care-units, mechanical ventilation and in-hospital mortality. In multiple regression analyses, incident arrhythmia was strongly associated with duration of hospitalization and mechanical ventilation. Cardiovascular disease was associated with increased mortality. Conclusions: Arrhythmia was the most common cardiac event in association with hospitalization for COVID-19. Older age and cardiovascular disease predisposed for arrhythmia during hospitalization. Whereas in-hospital mortality is affected by underlying cardiovascular conditions, arrhythmia during hospitalization for COVID-19 is independently associated with prolonged hospitalization and mechanical ventilation. Thus, incident arrhythmia may indicate a patient subgroup at risk for a severe course of disease. MDPI 2021-01-02 /pmc/articles/PMC7796041/ /pubmed/33401735 http://dx.doi.org/10.3390/jcm10010133 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zylla, Maura M.
Merle, Uta
Vey, Johannes A.
Korosoglou, Grigorios
Hofmann, Eva
Müller, Michael
Herth, Felix
Schmidt, Werner
Blessing, Erwin
Göggelmann, Christoph
Weidner, Norbert
Fiedler, Mascha O.
Weigand, Markus A.
Kälble, Florian
Morath, Christian
Leiner, Johannes
Kieser, Meinhard
Katus, Hugo A.
Thomas, Dierk
Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19
title Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19
title_full Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19
title_fullStr Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19
title_full_unstemmed Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19
title_short Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19
title_sort predictors and prognostic implications of cardiac arrhythmias in patients hospitalized for covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796041/
https://www.ncbi.nlm.nih.gov/pubmed/33401735
http://dx.doi.org/10.3390/jcm10010133
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